Radiation-induced-thymic lymphoma occurs in young, but not in old mice
Radiation-induced-thymic lymphoma occurs in young, but not in old mice
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DOI：
10.1016/s0014-4800(03)00026-1
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发表时间：
2003-06-01
影响因子：
3.6
通讯作者：
Hirokawa, K
中科院分区：
文献类型：
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作者：
Utsuyama, M;Hirokawa, K
暴露于分次全身照射的幼鼠发生胸腺淋巴瘤。通过使用年轻和年老的小鼠，我们研究了年龄对小鼠辐射诱导的胸腺淋巴瘤发生的影响。实验一：将新生胸腺移植到青年和老年小鼠的肾被膜下，然后进行分次全身照射。在第二次和第三次实验中。通过将来自年轻小鼠和老年小鼠的骨髓细胞移植到年轻小鼠和老年小鼠中，构建了四种骨髓嵌合体组合。然后将新生胸腺移植到嵌合体小鼠体内，并进行分次全身照射。本研究结果提示胸腺淋巴瘤的发病受胸腺微环境、骨髓等年龄因素的影响。和宿主环境。如果他们都是年轻人，胸腺淋巴瘤的发病率很高。如果其中一个是旧的，发病率肯定会下降。胸腺淋巴瘤从未发生在旧胸腺环境中，即使在存在年轻胸腺细胞的情况下。总之，FWI治疗后诱发胸腺淋巴瘤存在年龄优势，老年因素存在时发生率明显降低。(C)2003 Elsevier Science（美国）。All rights reserved.
Young mice exposed to fractionated whole-body irradiation develop thymic lymphoma. By using young and old mice, we examined the effect of age on the occurrence of radiation-induced thymic lymphoma in mice. In the first experiment, young and old mice were grafted with newborn thymus under kidney capsule and then treated with fractionated whole-body irradiation (FWI). In the second and third experiments. four combinations of bone marrow chimeras were constructed by transplanting bone marrow cells from young and old mice into young and old mice. Then these chimera mice were grafted with newborn thymus and treated with fractionated whole-body irradiation. The results in the present study indicate that the incidence of thymic lymphoma is influenced by age factors of thymic microenvironment, bone marrow. and host environment. If they are all young, the incidence of thymic lymphoma is high. If one of these is old, the incidence definitely decreases. Thymic lymphoma never occurred in old thymic environment even in the presence of young thymocytes. In conclusion, age advantage is present in the induction of thymic lymphoma after the treatment with FWI and the incidence definitely decreases in the presence of old factors. (C) 2003 Elsevier Science (USA). All rights reserved.