Functional improvement and neurogenesis after collagen-GAG matrix implantation into surgical brain trauma
Functional improvement and neurogenesis after collagen-GAG matrix implantation into surgical brain trauma
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DOI：
10.1016/j.biomaterials.2011.11.040
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发表时间：
2012-03-01
期刊：
影响因子：
14
通讯作者：
Wang, Jia-Yi
中科院分区：
文献类型：
--
作者：
Huang, Kuo-Feng;Hsu, Wei-Cherng;Wang, Jia-Yi
手术或创伤性脑损伤通常会导致脑实质的丢失，但目前还没有临床上有效的神经再生策略。胶原蛋白-氨基葡聚糖(胶原-GAG，CG)支架以前在体内的许多组织中使用过，但从未在大脑中使用过。利用动物模型，我们研究了外科脑损伤后植入CG支架基质的效果。结果表明，CG支架植入可明显促进颅脑损伤后功能恢复。研究发现，CG支架可以促进内源性神经前体细胞在基质内区(IMZ)和病变边界区(LBZ)的增殖、分化和迁移。颅脑损伤后植入CG支架后，脑源性神经营养因子(BDNF)和胶质源性神经营养因子(GDNF)的组织浓度持续升高。这些结果表明，使用CG支架可作为脑损伤后组织再生和功能恢复的一种潜在的临床策略。(C)2011爱思唯尔有限公司。保留所有权利。
Surgical or traumatic brain injury often leads to loss of cerebral parenchyma but there is as yet no clinically effective strategy for neural regeneration. Collagen glycosaminoglycan (collagen-GAG, CG) scaffolds have previously been used in many tissues in vivo but have never been utilized in the brain. Using an animal model, we investigated the effects of the implantation of CG scaffold matrix following surgical brain trauma. Results indicated that implantation of CG scaffold could significantly promote functional recovery following surgical brain trauma. The CG scaffold was found to facilitate proliferation, differentiation and migration of endogenous neural precursor cells (NPCs) both in the intra-matrix zone (IMZ) and lesion boundary zone (LBZ). The tissue concentration of brain-derived neurotrophic factor (BDNF) and glia-derived neurotrophic factor (GDNF) in the cortex demonstrated a sustained increase after implantation of CG scaffold following surgical brain trauma. These results suggest that the utilization of CG scaffolds can be considered as a potential clinical strategy for tissue regeneration and functional recovery after brain injury. (C) 2011 Elsevier Ltd. All rights reserved.