Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three
Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three
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DOI：
10.1016/j.jaci.2009.10.009
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发表时间：
2009-12-01
影响因子：
14.2
通讯作者：
Asher, M. Innes
中科院分区：
文献类型：
--
作者：
Odhiambo, Joseph A.;Williams, Hywel C.;Asher, M. Innes
背景：1999年，国际儿童哮喘和过敏症研究(ISAAC)第一阶段报告了使用标准化流行病学工具在56个国家154个中心的715,033名儿童中湿疹症状的患病率。目的：更新5到10年后的世界湿疹流行地图(ISAAC第三阶段)，并包括来自100多个新中心的额外数据。方法：使用ISAAC关于湿疹症状的横断面调查问卷，由13-14岁的青少年和6-7岁儿童的父母完成。目前的湿疹被定义为过去12个月内出现的挠性瘙痒皮疹，如果与每周睡眠障碍至少一晚有关，则被认为是严重的湿疹。结果：对于6到7岁的年龄组，来自60个国家的143个中心的385,853名参与者的数据显示，当前湿疹的患病率在印度从0.9%到厄瓜多尔的22.5%不等，最新数据显示亚洲和拉丁美洲的患病率很高。对于13至14岁的年龄组，来自96个国家的230个中心的663,256名参与者的数据显示，患病率从中国的0.2%到哥伦比亚的24.6%不等，非洲和拉丁美洲的患病率最高。目前的湿疹男孩低于女孩(在6至7岁和13至14岁时，优势比分别为0.94和0.72)。结论：Isaac第三阶段提供了关于湿疹症状流行率的全面全球数据，这对公共卫生规划至关重要。新的数据显示，湿疹是一种发展中国家和发达国家的疾病。(《过敏与免疫杂志》2009；124：1251-8。)
Background: In 1999, The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One reported the prevalence of eczema symptoms in 715,033 children from 154 centers in 56 countries by using standardized epidemiologic tools.Objective: To update the world map of eczema prevalence after 5 to 10 years (ISAAC Phase Three) and include additional data from over 100 new centers.Methods: Cross-sectional surveys using the ISAAC questionnaire on eczema symptoms were completed by adolescents 13 to 14 years old and by parents of children 6 to 7 years old. Current eczema was defined as an itchy flexural rash in the past 12 months and was considered severe eczema if associated with I or more nights per week of sleep disturbance.Results: For the age group 6 to 7 years, data on 385,853 participants from 143 centers in 60 countries showed that the prevalence of current eczema ranged from 0.9% in India to 22.5% in Ecuador, with new data showing high values in Asia and Latin America. For the age group 13 to 14 years, data on 663,256 participants from 230 centers in 96 countries showed prevalence values ranging from 0.2% in China to 24.6% in Columbia with the highest values in Africa and Latin America. Current eczema was lower for boys than girls (odds ratio, 0.94 and 0.72 at ages 6 to 7 years and 13 to 14 years, respectively).Conclusion: ISAAC Phase Three provides comprehensive global data on the prevalence of eczema symptoms that is essential for public health planning. New data reveal that eczema is a disease of developing as well as developed countries. (J Allergy Clin Immunol 2009;124:1251-8.)