The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation
The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation
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DOI：
10.1177/0890334408317435
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发表时间：
2008-08-01
影响因子：
2.6
通讯作者：
Rodriguez, Juan M.
中科院分区：
文献类型：
--
作者：
Fernandez, Leonides;Delgado, Susana;Rodriguez, Juan M.
8例临床表现为葡萄球菌性乳腺炎的女性随机分为两组。将细菌素nisin （6 tg/mQ）溶液涂抹在nisin组的乳头和乳晕上2周，并将不含nisin的类似制剂涂抹在对照组上。第0天，乳杆菌素组与对照组乳汁葡萄球菌计数相近（分别为5.04 0.19和4.88 0.21 log,0 CFU/mL）。然而，在第14天，nisin组的平均值（3.22 0.43 log,, CFU/mL）低于对照组的平均值（5.01 0.21 log,0 CFU/mL）。nisin组的妇女在第14天没有观察到乳腺炎的临床症状，而对照组的妇女在整个研究过程中一直存在乳腺炎症状。总之，nisin似乎是一种有效的替代抗生素治疗葡萄球菌性乳腺炎。
Eight women with clinical signs of staphylococcal mastitis were randomly divided in 2 groups. A solution of the bacteriocin nisin (6 tg/mQ was applied to the nipple and mammary areola of those assigned to the nisin group for 2 weeks, and a similar preparation devoid of nisin was applied to the control group. On day 0, staphylococcal counts in breast milk of the nisin and control groups were similar (5.04 0.19 and 4.88 0.21 log,0 CFU/mL, respectively). However, on day 14, the mean in the nisin group (3.22 0.43 log,, CFU/mL) was statistically lower than that of the control group (5.01 0.21 log,0 CFU/mL). No clinical signs of mastitis were observed among the women of the nisin group on day 14, whereas they persisted throughout the study in the women of the control group. In conclusion, nisin seems to be an efficient alternative to antibiotics for the treatment of staphylococcal mastitis.