Non-adhesive PEG hydrogel nanostructures for self-assembly of highly ordered colloids
Non-adhesive PEG hydrogel nanostructures for self-assembly of highly ordered colloids
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DOI：
10.1088/0957-4484/20/7/075307
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发表时间：
2009-02-18
期刊：
影响因子：
3.5
通讯作者：
Pan, Tingrui
中科院分区：
文献类型：
--
作者：
Cong, Hailin;Revzin, Alexander;Pan, Tingrui
在本文中，我们报道了图案化的非粘性水凝胶纳米表面对高度有序胶体自组装的影响。本研究采用聚乙二醇（PEG）水凝胶作为衬底材料，因为它具有理想的不粘接性能、生物相容性和光模压性。使用紫外或深紫外曝光，将超细PEG特征光刻到玻璃基板上，最小特征分辨率为500 nm。通过简单地控制纳米组装溶液的胶体浓度和孔的尺寸，在聚乙二醇孔内形成了一系列高度组织化的纳米胶体图案。与传统的表面修饰技术不同，我们的技术利用PEG水凝胶独特的不粘附特性，在模式辅助纳米组装中实现了极高的选择性。我们的实验表明，氧等离子体处理后，聚乙二醇表面的非粘附性能显著下降，导致在相同的加工条件下，纳米胶体珠的非选择性组装完全覆盖表面。因此，受益于独特的非粘附表面特性，模式辅助纳米组装方法为胶体纳米制造提供了高度可预测和稳健的过程，并且获得的具有良好组织模式的纳米胶体阵列可能在光子晶体制造，生物传感和分析检测中找到潜在的应用。
In this paper, we report on the effect of patterned non-adhesive hydrogel nanosurfaces on the self-assembly of highly ordered colloids. Polyethylene glycol (PEG) hydrogel is employed as the substrate material in the study, for its desired non-adhesive property, and biocompatibility as well as photopatternability. Ultrafine PEG features are photopatterned onto glass substrates with minimal feature resolution of 500 nm using ultraviolet or deep ultraviolet exposure. By simply controlling the colloidal concentration of the nanoassembly solutions and the dimensions of the wells, a range of highly organized nanocolloidal patterns are formed inside the PEG wells. Unlike the traditional surface modification techniques, ours takes advantage of the unique non-adhesive property of PEG hydrogels to achieve extremely high selectivity in the pattern-assisted nanoassembly. Our experiments show that with oxygen plasma treatment, the non-adhesive property of the PEG surface deteriorates significantly, leading to non-selective assembly with complete surface coverage of nanocolloidal beads under the same processing condition. Therefore, benefiting from the unique non-adhesive surface property, the pattern-assisted nanoassembly method enables a highly predictable and robust process for colloidal nanofabrication, and the obtained nanocolloidal arrays with well organized patterns could potentially find applications in photonic crystal fabrication, biological sensing and analytical detection.