Further characterizations of the nature of the behavioral and neurochemical effects of lesions to the nucleus basalis of Meynert in the rat.
Further characterizations of the nature of the behavioral and neurochemical effects of lesions to the nucleus basalis of Meynert in the rat.
复制标题
大鼠 Meynert 基底核损伤的行为和神经化学效应性质的进一步表征。
DOI：
10.1016/0197-4580(85)90030-2
复制
发表时间：
1985
影响因子：
4.2
通讯作者：
Berman,RF
中科院分区：
文献类型：
--
作者：
Altman,HJ;Crosland,RD;Jenden,DJ;Berman,RF
--越来越多的证据表明，基底前脑胆碱能系统在记忆过程中发挥着重要作用。胆碱能投射到新皮质的主要来源似乎是Meynert基底核(NBM)区域的大细胞神经元。我们采用立体定向的方法，向大鼠双侧延髓核内注射0.5μL鹅膏油酸(14μg//gm1)，观察双侧延髓核损毁对大鼠回避训练保持能力的影响。两周后，大鼠接受被动回避训练，并在5分钟、30分钟或24小时后测试其对原有回避习惯的保持情况。在训练后30分钟和24小时，与非手术对照组相比，NBM损伤的大鼠表现出明显的电击回避能力，但在5分钟时不明显。损伤动物的皮质胆碱乙酰转移酶(CAT)和乙酰胆碱酯酶(AChE)活性也显著降低。未观察到M受体结合或血浆胆碱酯酶活性的差异。结果表明，NBM损伤作为研究基底前脑胆碱能系统在记忆过程中作用的模型是有用的。
—Converging lines of evidence indicate an important role for the basal forebrain cholinergic system in memory processes. The principal origin of the cholinergic projection to the neocortex appears to be the magnocellular neurons in the region of the nucleus basalis of Meynert (NbM). We examined the effects of bilateral lesions of the NbM on retention of shock avoidance training by stereotaxically injecting rats with 0.5 μl of ibotenic acid (14 μg//gm1) into the NbM. Two weeks later rats were given passive avoidance training and tested for retention of the original avoidance habit 5 min, 30 min, or 24 hr later. Rats with lesions of the NbM showed significantly impaired shock avoidance performance compared to non-operated controls at both 30 min and 24 hr, but not at 5 min after training. Lesioned animals also showed a significant decrease in cortical choline acetyltransferase (CAT) and acetylcholinesterase (AChE) activities. No differences in muscarinic receptor binding or plasma cholinesterase activity was observed. The results demonstrate the usefulness of NbM lesions as a model for studying the role of the basal forebrain cholinergic system in memory processes.