IFN-1 Bid crosstalk: foe or friend to stem cells.
IFN-1 Bid crosstalk: foe or friend to stem cells.
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DOI：
10.21037/sci.2017.02.06
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发表时间：
2017-02
影响因子：
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通讯作者：
Pratibha Singh;L. Pelus
中科院分区：
文献类型：
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作者：
Pratibha Singh;L. Pelus
在稳定状态下，骨髓中大约70%的造血干细胞和祖细胞(HSPC)处于静止状态，糖酵解代谢产物(1)提供了低代谢活性。然而，为了应对外源性需求，如细胞丢失或损坏，或感染，它们变得高度增殖，并能有效和快速地扩张或重建血液和免疫系统(2，3)。
Under steady-state approximately 70% of the hematopoietic stem and progenitor cells (HSPC) in the bone marrow are quiescent, with low metabolic activity fueled by glycolytic metabolites (1). However, in response to exogenous demands such as cell loss or damage, or infection, they become highly proliferative and can efficiently and quickly expand or reconstitute the blood and immune systems (2,3).