Effects of stimulus spectral contrast on receptive fields of dorsal cochlear nucleus neurons.-猫眼课题宝

刺激光谱对比度对耳蜗背核神经元感受野的影响。

DOI：

10.1152/jn.01239.2006

发表时间：

2007

期刊：

Journal of neurophysiology

影响因子：

2.5

通讯作者：

中科院分区：

医学3区

文献类型：

作者：

Reiss,LinaAJ;Bandyopadhyay,Sharba;Young,EricD

Neurons in the dorsal cochlear nucleus (DCN) exhibit strong nonlinearities in spectral processing. Low-order models that transform the stimulus spectrum into discharge rate using a combination of first- and second-order weighting of the spectrum (quadratic models) usually fail to predict responses to novel stimuli for principal neurons in the DCN, even though they work well in ventral cochlear nucleus. Here we investigate the effects of spectral contrast on the performance of such models. Typically, the models fail for stimuli with natural-sound–like spectral contrasts (∼12 dB), but have good prediction performance at small (3-dB) contrasts. The weights also typically increase substantially in amplitude at smaller spectral contrast. These changes in weight size with contrast are partly inherited from similar effects seen in auditory nerve fibers, but there must be additional effects from inhibitory circuits in the DCN. These results provide insight into the reasons for the poor performance of spectrotemporal receptive field (STRF) models in predicting responses of auditory neurons. Because the general shapes of the weights do not change between low and high contrast, they also suggest that STRFs may capture meaningful properties of neural receptive fields, even though they do not do well at predicting responses.