A Working Threshold for Acute Nocturnal Melatonin Suppression from White Light Sources used in Architectural Applications
A Working Threshold for Acute Nocturnal Melatonin Suppression from White Light Sources used in Architectural Applications
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DOI：
10.4172/2157-2518.1000150
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
M. Rea;M. Figueiro
中科院分区：
文献类型：
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作者：
M. Rea;M. Figueiro
视网膜光线暴露会减少夜间褪黑激素的产生。由于夜间光线抑制褪黑激素被认为是一种内分泌干扰物，并与某些疾病，如糖尿病、肥胖和癌症有关，因此能够估计可靠地抑制褪黑激素所需的阈值光照水平是很重要的。这项研究的目的是为人们在其生活环境中可能经历的“白”光抑制褪黑激素制定一个工作阈值。28名受试者参与了两项研究。除了黑暗的对照夜晚，受试者被暴露在8、22和60勒克斯的角膜(研究1，n=14)和60、200和720勒克斯的“温白”光源(相关色温为2670K)下(研究2，n=14)。这些角膜照度水平转化为1%、2%、6%、19%和42%的模型褪黑素抑制水平。在这两项研究中，参与者在实验室呆了四个晚上，间隔一周。一个血液样本在午夜在昏暗的光线下提取，另一个血液样本在每种光照条件(包括黑暗)下暴露60分钟后提取。使用α？<；0.05I型误差的正统统计标准，只有200Lux和720lux的曝光产生了显著的抑制水平(分别为19%和37%)。基于对冷白光(6500K)的抑制水平为5%的标准，提出了将大多数建筑照明应用中使用的白光源的角膜光暴露30勒克斯持续30分钟作为夜间褪黑激素抑制的保守假设工作阈值。
Retinal light exposures can decrease melatonin production at night. Since nocturnal melatonin suppression by light has been implicated as an endocrine disruptor and linked to certain diseases, such as diabetes, obesity and cancer, it is important to be able to estimate a threshold light level needed to reliably suppress melatonin. The present study was designed to develop a working threshold for melatonin suppression from “white” light that might be experienced by people in their living environments. Twenty-eight subjects participated in two studies. In addition to dark, control nights, subjects were exposed to 8, 22, and 60 lux at the cornea (study 1, n=14) and to 60, 200, and 720 lux (study 2, n=14) of a “warm white” light source (correlated color temperature of 2670 K). These corneal illuminance levels translate to modeled melatonin suppression levels of 1%, 2%, 6%, 19%, and 42%. In both studies, participants came to the laboratory for four nights, separated by one week. One blood sample was drawn in dim light at midnight and another blood sample was drawn after 60-minute exposure to each light condition (including dark). Using an orthodox statistical criterion for a Type I error of α?< 0.05, only the 200 lux and the 720 lux exposures produced significant suppression levels (19% and 37%, respectively). Based upon a criterion modeled suppression level of 5% for a “cool white” light (6500 K), a corneal light exposure of 30 lux for 30 minutes from “white” light sources used in most architectural lighting applications is proposed as a conservative hypothesized working threshold for nocturnal melatonin suppression.