Post-transplantation primary central nervous system lymphoma in a patient with systemic lupus erythematosus and prolonged use of immunosuppressant.
Post-transplantation primary central nervous system lymphoma in a patient with systemic lupus erythematosus and prolonged use of immunosuppressant.
复制标题
患有系统性红斑狼疮且长期使用免疫抑制剂的患者的移植后原发性中枢神经系统淋巴瘤。
DOI：
--
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Y. Po
中科院分区：
文献类型：
--
作者：
T. Tse;Allan N L Chan;T. K. Chan;Y. Po
移植后原发性中枢神经系统淋巴瘤是一种罕见的和致命的移植后淋巴组织增生性疾病。此类淋巴瘤在文献中仅在少数病例系列中有描述。这种情况的发生率随着器官移植后生存率的提高而上升。一例移植后原发性中枢神经系统淋巴瘤在一个年轻的中国女性系统性红斑狼疮在这里描述。她在入院前2周拔牙后出现右侧无力和记忆丧失。脑的对比计算机断层扫描显示在左额叶上有一个对比边缘增强的病变。根据近期牙科手术史、长期免疫抑制治疗和计算机断层扫描结果，高度怀疑脑脓肿。进行了紧急手术。组织学检查显示移植后原发性中枢神经系统淋巴瘤，B细胞标记物CD20阳性。停用免疫抑制剂，并接受放疗和利妥昔单抗（抗CD20单克隆抗体）治疗。她在16个月时保持无病。移植术后原发性中枢神经系统淋巴瘤是一种罕见的肿瘤，其临床表现和影像学特征各不相同。我们认为利妥昔单抗可能在治疗此类淋巴瘤中发挥作用。
Post-transplantation primary central nervous system lymphoma is an uncommon and fatal post-transplant lymphoproliferative disorder. Such lymphomas have been described in only a few case series in the literature. The incidence of this condition is rising with improved survival after organ transplantation. A case of post-transplantation primary central nervous system lymphoma in a young Chinese woman with systemic lupus erythematosus is described here. She presented with right-sided weakness and memory loss after tooth extraction 2 weeks before admission. Contrast computed tomography of the brain demonstrated a contrast rim-enhancing lesion over the left frontal lobe. With a history of recent dental procedure, long-term immunosuppressive therapy and computed tomography findings, cerebral abscess was highly suspected. Emergency operation was performed. Histopathology showed post-transplantation primary central nervous system lymphoma, with cells positive for B-cell marker CD20. Immunosuppressant was stopped and she was treated with radiotherapy and rituximab (anti-CD20 monoclonal antibody). She remained disease-free at 16 months. Post-transplantation primary central nervous system lymphoma is rare with variable presentation and radiological features. We believe rituximab may have a role in the treatment of such lymphomas.
DOI：
10.1016/0360-3016(92)90538-s
发表时间：
1992-01-01
影响因子：
7
作者：
NELSON, DF;MARTZ, KL;MURRAY, KJ
通讯作者：
MURRAY, KJ