Nitrogen supported solvent evaporation using continuous-flow microfluidics
Nitrogen supported solvent evaporation using continuous-flow microfluidics
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DOI：
10.1039/c2ra21876c
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发表时间：
2012-01-01
期刊：
影响因子：
3.9
通讯作者：
Dittrich, Petra S.
中科院分区：
文献类型：
--
作者：
Cvetkovic, Benjamin Z.;Lade, Oliver;Dittrich, Petra S.
在这项工作中，我们展示了一个连续操作的微流体装置，用于溶剂去除和交换，通过支持气体进行化学合成。该玻璃装置由三个部分组成：（i）三个合并的微通道，以产生环形气液流;（ii）下面具有加热器的蛇形通道，以允许挥发性溶剂的有效蒸发;（iii）具有侧毛细管的部分，以将液体与气相分离。我们证明了从乙腈-水混合物中去除乙腈的设备的性能。在流速为20-30 mL min 21和氮气压力为1.2 bar的情况下，我们在几秒钟内实现了乙腈的高效去除。在三个步骤中，乙腈从进料溶液中的50重量%减少到最终溶液中的1重量%。我们相信，该装置可以很容易地应用于其他溶剂混合物。
In this work we demonstrate a continuously operating microfluidic device for solvent removal and exchange for chemical syntheses by means of a supporting gas. The glass device consists of three sections: (i) three merging microchannels to create an annular gas-liquid stream; (ii) a serpentine channel with a heater underneath to allow efficient evaporation of the volatile solvent; (iii) a section with side capillaries to separate the liquid from the gas phase. We demonstrate the performance of the device for the removal of acetonitrile from an acetonitrile-water mixture. We achieved efficient removal of acetonitrile within a few seconds for flow rates of 20-30 mL min 21 and a nitrogen pressure of 1.2 bar. In three steps, acetonitrile was reduced from 50 wt% in the feed solution to 1 wt% in the final solution. We believe that the device can be easily applied to other solvent mixtures.