Low secretory IgA concentrations in oral secretions during the acute phase of infectious mononucleosis.
Low secretory IgA concentrations in oral secretions during the acute phase of infectious mononucleosis.
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传染性单核细胞增多症急性期口腔分泌物中分泌型 IgA 浓度较低。
DOI：
10.3109/00365548409070396
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发表时间：
1984
影响因子：
--
通讯作者：
C. Lundberg
中科院分区：
文献类型：
--
作者：
G. Marklund;B. Carlsson;C. Lundberg
虽然EB病毒(EBV)与传染性单核细胞增多症(IM)的关系已经得到很好的证实，但为什么在原发EBV感染期间IM不是强制性的，这个问题还没有解决。假设口咽分泌性免疫功能不全可能是IM的一个病因成分，研究了IM急性期口腔分泌物中的分泌型IgA浓度。IM患者(n=18)血清分泌型免疫球蛋白A浓度较低，平均值为0.180 g/L，与正常对照组(n=10)比较，平均值为0.680 g/L，且在IM急性期呈下降趋势。未见相应的血清IgA下降。调查还发现，号称对治疗心绞痛有益的替硝唑并不影响唾液分泌IgA的浓度。
Although the Epstein-Barr virus (EBV) relation to infectious mononucleosis (IM) has been well established, the question why IM is not compulsory during a primary EBV infection has yet to be solved. Assuming a possible oropharyngeal secretory immunoincompetence as an etiological component of IM, the secretory IgA concentrations in oral secretions during the acute phase of IM was investigated. Low concentrations of secretory IgA in IM patients (n = 18) were found, mean value 0.180 g/l as compared to those in healthy controls (n = 10), mean value 0.680 g/l. Furthermore, diminishing concentrations of secretory IgA were found during the acute phase of IM. There was no corresponding serum IgA decrease. The investigation also revealed that tinidazole, claimed to be beneficial in the treatment of anginous IM, did not affect the concentrations of spit secretory IgA.