Effects of endocrine disruptors on obesity
Effects of endocrine disruptors on obesity
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DOI：
10.1111/j.1365-2605.2007.00858.x
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发表时间：
2008-04-01
影响因子：
--
通讯作者：
Heindel, Jerrold J.
中科院分区：
文献类型：
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作者：
Newbold, Retha R.;Padilla-Banks, Elizabeth;Heindel, Jerrold J.
环境中具有类雌激素活性的化学品可扰乱围产期建立的内分泌信号通路的程序，并导致不良后果，这些后果可能要到生命后期才明显。越来越多的证据表明，发育暴露于环境激素模拟物，对男性和女性的不良健康后果越来越多。最近，肥胖被认为是在发育的关键阶段暴露于内分泌干扰化学品（EDCs）的另一种不良健康影响。肥胖正在迅速成为一个重大的人类健康危机，因为它在世界范围内达到流行病的比例，并与糖尿病和心血管疾病等慢性疾病有关。在这篇综述中，我们总结了文献报道的协会内分泌干扰物和肥胖症的发展，并进一步描述了一种动物模型暴露于己烯雌酚，已被证明是有用的研究机制参与异常编程的各种雌激素靶组织在分化过程中。总之，这些数据表明了内分泌干扰物异常编程的新目标（即脂肪细胞分化和参与体重稳态的机制），并提供了支持“成人疾病的发育起源”这一科学术语的证据。内分泌干扰物和肥胖症的关联的新想法将对肥胖症的关注从干预和治疗扩展到包括预防和避免这些化学改性剂。
Environmental chemicals with hormone-like activity can disrupt the programming of endocrine signalling pathways that are established during perinatal life and result in adverse consequences that may not be apparent until much later in life. Increasing evidence implicates developmental exposure to environmental hormone mimics with a growing list of adverse health consequences in both males and females. Most recently, obesity has been proposed to be yet another adverse health effect of exposure to endocrine disrupting chemicals (EDCs) during critical stages of development. Obesity is quickly becoming a significant human health crisis because it is reaching epidemic proportions worldwide, and is associated with chronic illnesses such as diabetes and cardiovascular disease. In this review, we summarize the literature reporting an association of EDCs and the development of obesity, and further describe an animal model of exposure to diethylstilbestrol that has proven useful in studying mechanisms involved in abnormal programming of various oestrogen target tissues during differentiation. Together, these data suggest new targets (i.e. adipocyte differentiation and mechanisms involved in weight homeostasis) of abnormal programming by EDCs, and provide evidence that support the scientific term 'the developmental origins of adult disease'. The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers.