TOTTERING - A NEUROMUSCULAR MUTATION IN MOUSE
TOTTERING - A NEUROMUSCULAR MUTATION IN MOUSE
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DOI：
10.1093/oxfordjournals.jhered.a107180
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发表时间：
1962-01-01
影响因子：
3.1
通讯作者：
SIDMAN, RL
中科院分区：
文献类型：
--
作者：
GREEN, MC;SIDMAN, RL
一种新的隐性突变，称为蹒跚，tq，与少并指（趾）畸形密切相关。纯合子蹒跚小鼠的特征是早在2周龄时就可能开始并持续一生的间歇性癫痫发作，以及步态不稳，特别影响后躯，可能在4周龄前出现，但在某些种群中直到8周龄或更长时间才可检测到，并贯穿一生。蹒跚学步的老鼠，不论雌雄，通常都能生育。
A new recessive mutation, called tottering, tq, is very closely linked to Oligosyndactylism, Os. Homozygous tottering mice are characterized by intermittent seizures which may begin as early as 2 weeks of age and continue throughout life, and by a wobbly gait, affecting particularly the hindquarters, which may appear before 4 weeks of age but in some stocks is not detectable until 8 weeks or more, and which continues throughout life. Tottering mice of both sexes are often fertile.