Effects of beta-carotene repletion on beta-carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men.
Effects of beta-carotene repletion on beta-carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men.
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β-胡萝卜素补充对年轻男性β-胡萝卜素吸收、脂质过氧化和中性粒细胞超氧化物形成的影响。
DOI：
10.1080/01635589009514094
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Friedman,H
中科院分区：
文献类型：
--
作者：
Mobarhan,S;Bowen,P;Andersen,B;Evans,M;Stacewicz-Sapuntzakis,M;Sugerman,S;Simms,P;Lucchesi,D;Friedman,H
β-胡萝卜素的化学预防作用通常归因于其抗氧化特性。为了确定β-胡萝卜素补充剂对不同氧化代谢参数的影响，15名正常年轻男性受试者（18-30岁）在进入研究前接受了两周的无类胡萝卜素流质饮食。然后测量血液中的五种类胡萝卜素、视黄醇、棕榈酸视黄酯、视黄醇结合蛋白、α-生育酚、维生素C、锌、脂质过氧化物和中性粒细胞超氧化物生成。用15 mg β-胡萝卜素进行吸收试验，以确定每例受试者的吸收曲线。然后将受试者分为两组，每天给予15（n =7）或120（n =8）mg β-胡萝卜素，持续沿着相同的无类胡萝卜素流质饮食。重复进行吸收试验和血液测量。补充β-胡萝卜素后，两组的血清过氧化脂质水平均下降（p< 0.05），但中性粒细胞超氧化物生成或任何维生素水平均未观察到其他变化。与维生素E相反，β-胡萝卜素的超氧化物清除能力显然不会有助于其降低血清脂质过氧化物水平的作用。
The chemopreventive effects of ß‐carotene are usually attributed to its antioxidant properties. To determine the effects of ß‐carotene supplementation on different parameters of oxidative metabolism, 15 normal young male subjects (18–30 yrs) were placed on a carotenoid‐free liquid diet for two weeks prior to entry into the study. Blood was then measured for five carotenoids, retinol, retinyl palmitate, retinol‐binding protein, α‐tocopherol, vitamin C, zinc, lipid peroxides, and neutrophil Superoxide production. Absorption tests were performed with 15 mg of ß‐carotene to determine absorption curves for each subject. Subjects were then divided into two groups and given either 15 (n =7) or 120 (n =8) mg of ß‐carotene daily for four weeks along with the same carotenoid‐free liquid diet. The absorption test and the blood measurements were repeated. After repletion with ß‐carotene, serum lipid peroxide levels decreased in both groups (p< 0.05), but no other changes were noted in either the neutrophil superoxide production or in the levels of any of the vitamins measured. In contrast to vitamin E, the superoxide scavenging ability of ß‐carotene apparently does not contribute to its effects in lowering serum lipid peroxide levels.