Cellular restriction factors affecting the early stages of HIV replication.
Cellular restriction factors affecting the early stages of HIV replication.
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DOI：
10.1007/s11904-006-0004-3
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发表时间：
2006-02-01
影响因子：
4.6
通讯作者：
Hope, Thomas J
中科院分区：
文献类型：
--
作者：
Perez, Omar;Hope, Thomas J
哺乳动物细胞中存在几种先天免疫机制，可防止病毒复制。这些细胞因子通过诱导在病毒进入后但在整合到宿主基因组中之前起作用的显性限制来影响逆转录病毒在哺乳动物细胞中的向性。最近发现了与HIV进入后阻断有关的几种细胞因子。这些最新的进展鉴定了三重基序蛋白5 α（Trim 5 α）和载脂蛋白B mRNA编辑酶催化多肽样3G（APOBEC 3G），它们对包括HIV-1在内的几种逆转录病毒起作用。这些细胞蛋白的限制机制尚不清楚。因此，本文重点介绍了了解Trim 5 alpha和APOBEC 3G功能的最新进展。
Several innate immune mechanisms exist in mammalian cells that prevent the replication of viruses. These cellular factors influence the tropism of retroviruses in mammalian cells by inducing a dominant restriction that acts after viral entry but before integration into the host genome. The identification of several cellular factors involved with the post entry block of HIV has recently been revealed. These recent advances identified the tripartite motif protein 5alpha (Trim5alpha) and the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G), which work to inactivate several retroviruses including HIV-1. The mechanism of restriction by these cellular proteins is unknown. Therefore, this review highlights recent advances in understanding the function of Trim5alpha and APOBEC3G.