Visual imagery and perception in posttraumatic stress disorder. A positron emission tomographic investigation.
Visual imagery and perception in posttraumatic stress disorder. A positron emission tomographic investigation.
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DOI：
10.1001/archpsyc.1997.01830150057010
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发表时间：
1997-03
影响因子：
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通讯作者：
L. Shin;S. Kosslyn;R. McNally;N. Alpert;W. Thompson;S. Rauch;M. L. Macklin;R. Pitman
中科院分区：
文献类型：
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作者：
L. Shin;S. Kosslyn;R. McNally;N. Alpert;W. Thompson;S. Rauch;M. L. Macklin;R. Pitman
背景：在暴露于与战斗有关的刺激期间，测量了有和没有创伤后应激障碍（PTSD）的越战老兵的相对局部脑血流量（rCBF）变化。方法采用正电子发射断层扫描（PET）检测7名创伤后应激障碍（PTSD）退伍军人和7名健康退伍军人（对照组）的rCBF。结果与对照组相比，创伤后应激障碍患者在产生战斗相关图片时，扣带回腹前区和右侧杏仁核的rCBF增加;在观看战斗图片时，创伤后应激障碍患者Broca区的rCBF减少。结论：研究结果表明，腹侧前扣带回和右侧杏仁核在患有PTSD的退伍军人对与战斗有关的场景的心理图像的反应中发挥作用。创伤后应激障碍的再体验现象，通常涉及情感视觉心理意象，可能同样与这些区域的rCBF增加有关。
BACKGROUND Relative regional cerebral blood flow (rCBF) changes were measured in Vietnam combat veterans with and without posttraumatic stress disorder (PTSD) during exposure to combat-related stimuli. METHODS Positron emission tomography was used to measure rCBF in 7 combat veterans with PTSD (PTSD group) and 7 healthy combat veterans (control group) who viewed and generated visual mental images of neutral, negative, and combat-related pictures. RESULTS Unlike control subjects, subjects with PTSD had increased rCBF in ventral anterior cingulate gyrus and right amygdala when generating mental images of combat-related pictures; when viewing combat pictures, subjects with PTSD showed decreased rCBF in Broca's area. CONCLUSIONS Results suggest that ventral anterior cingulate gyrus and right amygdala play a role in the response of combat veterans with PTSD to mental images of combat-related scenes. Reexperiencing phenomena of PTSD, which often involve emotional visual mental imagery, may be likewise associated with increased rCBF in these regions.