COMPARISON OF 3 TUMOR-MARKERS CA-125, LIPID-ASSOCIATED SIALIC-ACID (LSA), AND NB 70K - IN MONITORING OVARIAN-CANCER
COMPARISON OF 3 TUMOR-MARKERS CA-125, LIPID-ASSOCIATED SIALIC-ACID (LSA), AND NB 70K - IN MONITORING OVARIAN-CANCER
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DOI：
10.1016/0090-8258(90)90037-l
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发表时间：
1990-08-01
影响因子：
4.7
通讯作者：
HILSENBECK, S
中科院分区：
文献类型：
--
作者：
PETRU, E;SEVIN, BU;HILSENBECK, S
在152名侵袭性上皮性卵巢癌患者中研究了三种肿瘤标志物sbdCA-125、脂质相关唾液酸（LSA）和NB/70 Ksbd单独和组合的监测价值。CA-125的敏感性和特异性（分别为90%和92%）上级LSA（分别为79%和63%）和NB/70 K（分别为76%和74%）。Ca-125本身显示出与LSA或NB/70 K组合相同或更高的灵敏度以及更高的特异性。CA-125在87%的病例中预测癌症，LSA和NB/70 K分别为70%和57%。在第二次检查阴性的患者中，CA-125预测疾病状态的比例为93%，LSA和NB/70 K分别为54%和63%。根据这些数据，除了临床上确定的CA-125外，同时测定LSA和NB/70 K的价值似乎是有限的。这主要是由于LSA和NB/70 K缺乏特异性。然而，本研究中CA-125的灵敏度和特异性均在报告的上限范围内。
The monitoring value of three tumor markers.sbd.CA-125, lipid- associated sialic acid (LSA), and NB/70K.sbd.alone and in combination has been studied in 152 patients with invasive, epithelial ovarian cancer. The sensitivity and specificity of CA-125 (90 and 92%, respectively) were superior to those of LSA (79 and 63%, respectively) and NB/70K (76 and 74%, respectively). Ca-125 by itself showed equal or higher sensitivity as well as higher specificity than in combinations with either LSA or NB/70 K. CA-125 predicted cancer at second-look in 87% of cases as did LSA and NB/70K in 70 and 57%, respectively. In patients with negative second-look, CA-125 predicted the disease status in 93% as did LSA and NB/70K in 54 and 63%, respectively. On the basis of these data, the value of simultaneous determination of LSA and NB/70K, in addition to the clinically established CA-125, seems to be limited. This is due mainly to the lack of specificity of LSA and NB/70K. However, the sensitivity and specificity of CA-125 in this study were in the upper reported range.