Effects of diazoxide and hydrochlorothiazide on water permeability and sodium transport in the frog bladder.
Effects of diazoxide and hydrochlorothiazide on water permeability and sodium transport in the frog bladder.
复制标题
二氮嗪和氢氯噻嗪对青蛙膀胱水渗透性和钠转运的影响。
DOI：
10.1159/000137593
复制
发表时间：
1982
期刊：
影响因子：
3.1
通讯作者：
H. Shimada
中科院分区：
文献类型：
--
作者：
F. Marumo;T. Mishina;H. Shimada
研究了二氮嗪和氢氯噻嗪对加压素诱导的青蛙膀胱渗透水流量和钠转运增加的影响。二氮嗪增强加压素诱导的膀胱渗透水流量，但不影响环AMP或茶碱诱导的水流量。氢氯噻嗪不影响加压素诱导的水流量。我们的研究结果表明，二氮嗪通过抑制膀胱上皮细胞中磷酸二酯酶的活性来增加水流量，而氢氯噻嗪则没有。另一方面，两种药物均抑制膀胱膜的短路电流，抑制肾细胞的Na，K依赖性ATP酶活性。这些结果表明，这两种药物通过抑制Na，K-依赖性ATP酶活性来降低膀胱中的钠转运。
The effects of diazoxide and hydrochlorothiazide on vasopressin-induced increments in osmotic water flow and sodium transport across the frog bladder were studied. Diazoxide enhanced the vasopressin-induced osmotic water flow of the bladder, but did not affect the cyclic AMP- or theophylline-induced water flow. Hydrochlorothiazide did not affect the vasopressin-induced water flow. Our results suggest that diazoxide increased the water flow by inhibiting the activity of phosphodiesterase in bladder epithelial cells, whereas hydrochlorothiazide did not. On the other hand, both drugs suppressed the short-circuit current of the bladder membrane and inhibited the Na,K-dependent ATPase activity of the kidney cells. These results suggest that both drugs decreased sodium transport in the bladder by inhibiting Na,K-dependent ATPase activity.