Perivascular epithelioid cell tumor of the uterus: Immunohistochemical, ultrastructural and molecular study
Perivascular epithelioid cell tumor of the uterus: Immunohistochemical, ultrastructural and molecular study
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DOI：
10.1046/j.1440-1827.2003.01557.x
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发表时间：
2003-11-01
影响因子：
2.2
通讯作者：
Lee, ES
中科院分区：
文献类型：
--
作者：
Park, SH;Ro, JY;Lee, ES
报告1例子宫血管周围上皮样细胞瘤，发生在一个32岁的妇女。肿瘤（8.0厘米的大小）显示外生性生长的外一半的子宫肌层。组织学上，肿瘤由粗大的血管和血管周围的上皮样细胞组成。肿瘤细胞HMB 45抗原，CD 117（c-kit），波形蛋白和孕激素受体呈强免疫反应性，但完全阴性的S-100蛋白，平滑肌肌动蛋白，结蛋白，CD 34，雌激素受体和p16。Ki-67标记指数低（1.25%）。超微结构上，肿瘤细胞有大量的前黑素体和一些糖原沉积。p53单链DNA构象多态性和p16甲基化特异性聚合酶链反应均为阴性。血管平滑肌脂肪瘤同时表达HMB 45抗原和干细胞因子受体（CD 117），电镜下明确的黑素小体及HMB 45抗原和CD 117的共表达可能为了解血管周围上皮样细胞瘤提供线索。
A case of perivascular epithelioid cell tumor of the uterus is reported, occurring in a 32-year-old woman. The tumor (8.0 cm in dimension) showed exophytic growth from the outer half of the myometrium. Histopathologically, the tumor was composed of thick blood vessels and perivascular epithelioid cells. The neoplastic cells were strongly immunoreactive for HMB45 antigen, CD117 (c-kit), vimentin and the progesterone receptor, but completely negative for S-100 protein, smooth muscle actin, desmin, CD34, the estrogen receptor and p16. The Ki-67 labeling index was low (1.25%). Ultrastructurally, the neoplastic cells had numerous premelanosomes with some glycogen deposits. Single-stranded DNA conformational polymorphism of p53 and methylation-specific polymerase chain reaction of p16 revealed negative results. Definite melanosomes on electron microscopic analysis and coexpression of HMB45 antigen and stem cell factor receptor (CD117) may provide the clue to understanding perivascular epithelioid cell tumor because angiomyolipoma also coexpresses HMB45 antigen and CD117.