Protein synthesis in vitro, in the presence of Ca(OH)2-containing pulp-capping medicaments.
Protein synthesis in vitro, in the presence of Ca(OH)2-containing pulp-capping medicaments.
复制标题
在含 Ca(OH)2 盖髓药物存在下的体外蛋白质合成。
DOI：
10.1111/j.1600-0714.1983.tb00348.x
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Kim,JS
中科院分区：
文献类型：
--
作者：
Hanks,CT;Bergenholtz,G;Kim,JS
比较了四种含Ca（OH）2的盖髓药物对猴和人牙髓成纤维细胞早期传代培养物中蛋白质合成的影响。虽然蛋白质合成以及DNA合成被三种药物抑制，但当每天更换培养基时，在Life®存在下的人细胞培养物中的蛋白质合成速率上升至对照水平，但当培养基不更换时，蛋白质合成速率被抑制。这表明血清蛋白在炎症条件下对牙髓组织起保护作用，至少在Life®的情况下，允许成牙本质细胞分化并形成牙本质基质，而不受毒性组分或过量碱度的干扰。
Four Ca(OH)2‐containing pulp‐capping medicaments were compared for their effects on protein synthesis in early subcultures of monkey‐ and human‐pulpal fibroblasts. While protein synthesis, as well as DNA synthesis, was depressed by three of the medicaments, the protein‐synthetic rate in human‐cell cultures in the presence of Life® rose to control levels when the medium was changed daily, but was depressed when the medium was not changed. This suggests that serum proteins play a protective role for pulpal tissues under inflammatory conditions, at least in the case of Life®, allowing odontoblasts to differentiate and make dentinal matrix without interference of either toxic components or excess alkalinity.