Revascularization of immature necrotic teeth with platelet-rich fibrin and blood clot
Revascularization of immature necrotic teeth with platelet-rich fibrin and blood clot
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用富含血小板的纤维蛋白和血凝块对未成熟坏死牙齿进行血运重建
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
C. Yavagal
中科院分区：
文献类型：
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作者：
A. Prabhakar;N. Rani;C. Yavagal
背景：牙髓坏死的未成熟恒牙，不论有无根尖病变，牙髓治疗都面临着一些临床挑战。再生牙髓学是治疗这种未成熟坏死恒牙的一种很有前途的方法。目的：应用影像学和临床方法评价含富血小板纤维蛋白（PRF）和血凝块坏死牙髓的新生恒牙的再生潜力。设置和设计：这是一项比较两组的实验性体内研究。材料与方法：选取年龄在10 ~ 12岁的未成熟坏死恒牙14例，分为两组。1组采用常规血凝块重建术，2组采用PRF重建术。随访6个月。对根周愈合和根尖闭合的标准化x线片进行分析，并使用活动度指数与基线值进行临床分析。统计分析方法：采用Friedman检验、Wilcoxon检验和Mann-Whitney u检验对结果进行分析。结果：2组（PRF）在3个月和6个月时根周愈合和根尖闭合较1组（常规）有所增加。结论：PRF手术可使坏死的未成熟牙更快更好地愈合，降低放射率，加强根尖闭合，降低活动性。
Background: Endodontic treatment of immature permanent teeth with necrotic pulp, with or without apical pathosis, poses several clinical challenges. Regenerative endodontics is a promising alternative for the treatment of such immature necrotic permanent teeth. Aim: To assess the regenerative potential of young permanent teeth with necrotic pulps with platelet-rich fibrin (PRF) and blood clot using radiographic and clinical methods. Settings and Design: This was an experimental, in vivo study comparing the two groups. Materials and Methods: Immature necrotic permanent teeth (n = 14) in patients who belonged to the age group of 10-12 years were selected and divided into two groups. Group 1 was treated by conventional revascularization with blood clot and Group 2 with revascularization using PRF. Follow-up was done for 6 months. Standardized radiographs were analyzed for the periradicular healing and apical closure, and clinical analysis was performed using mobility index as compared to baseline values. Statistical Analysis Used: Results were analyzed using Friedman test, Wilcoxon test, and Mann-Whitney U-test. Results: There was increased periradicular healing and apical closure at 3 months and 6 months in Group 2 (PRF) when compared to Group 1 (conventional). Conclusions: Revascularization with PRF procedure leads to better and faster healing, reduced radiolucency, enhanced apical closure, and reduction in mobility of necrotic immature teeth.