Neonatal organizational effects of the 5-HT2 and 5-HT1A subsystems on adult behavior in the rat
Neonatal organizational effects of the 5-HT2 and 5-HT1A subsystems on adult behavior in the rat
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DOI：
10.1016/0091-3057(95)02134-5
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发表时间：
1996-05-01
影响因子：
3.6
通讯作者：
Wilson, CA
中科院分区：
文献类型：
--
作者：
Gonzalez, MI;Albonetti, E;Wilson, CA
雄性、雌性、新生儿雄激素化雌性和新生儿去势雄性在出生后第二周接受 0.25 mg/kg 5-HT2 激动剂 1-(2,5-二甲氧基-3-碘苯基)-2-氨基丙烷 HCl (DOI)、5-HT2 拮抗剂利坦色林 (Rit)、5-HT1A 激动剂治疗8-羟基-2-(二正丙氨基)四氢化萘 (8-OH-DPAT) 或 5-HT1A 拮抗剂 WAY100135 (WAY)。在成年期测量探索、焦虑、社会性偏好和性行为。作用于 5-HT1A 受体的药物似乎不会影响所研究的任何行为系统的组织。 DOI 增加了探索活动，但仅限于女性，这表明睾酮拮抗 5-HT2 活动对探索的刺激作用。新生儿利坦色林选择性地减少女性的焦虑，而 DOI 对雄激素化的女性也有类似的作用。这表明新生儿5-HT2活性对于正常女性是致焦虑的，对于雄激素化女性是抗焦虑的，而对男性的焦虑没有影响。雄性和雄激素化的雌性都表现出对雌性挑逗的偏好，这种偏好已被 5-HT2 激动剂 DOI 废除。这些结果指出，5-HT2 活性选择性抑制新生儿睾酮存在下诱导的异性恋偏好。 DOI 还减少了男性的男性性行为和雄激素化女性的女性性行为。因此，5-HT2系统拮抗睾酮刺激异性取向和性活动的作用，并且这与遗传性别无关。
Males, females, neonatally androgenized females, and neonatally castrated males were treated over the second week of life with 0.25 mg/kg of either the 5-HT2 agonist 1-(2,5-dimethoxy-3-iodophenyl)-2-aminopropane HCl (DOI), the 5-HT2 antagonist ritanserin (Rit), the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), or the 5-HT1A antagonist WAY100135 (WAY). Exploration, anxiety, sociosexual preferences, and sexual behavior were measured in adulthood. Agents acting on 5-HT1A receptors do not appear to affect organization of any of the behavioral systems studied. DOI increased exploratory activity but in females only, which suggests that testosterone antagonizes the stimulatory effect of 5-HT2 activity on exploration. Neonatal ritanserin selectively reduced anxiety in females, and DOI had a similar effect in androgenized females. This indicates that neonatal 5-HT2 activity is anxiogenic in normal females, anxiolytic in androgenized females, and has no effect on anxiety in males. Males and androgenized females both showed a preference for the female teaser that was abolished by the 5-HT2 agonist, DOI. These results point out that 5-HT2 activity selectively suppresses heterosexual preference induced in the presence of neonatal testosterone. DOI also reduced both male sexual behavior in males and female sexual behavior in androgenized females. Thus, the 5-HT2 system antagonizes the action of testosterone in stimulating heterosexual orientation and sexual activity, and this is independent of genetic sex.