Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs.
Recent advances regarding the role of ABC subfamily C member 10 (ABCC10) in the efflux of antitumor drugs.
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DOI：
10.5732/cjc.013.10122
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发表时间：
2014-05
影响因子：
--
通讯作者：
Chen ZS
中科院分区：
文献类型：
--
作者：
Kathawala RJ;Wang YJ;Ashby CR Jr;Chen ZS
ABCC10, also known as multidrug-resistant protein 7 (MRP7), is the tenth member of the C subfamily of the ATP-binding cassette (ABC) superfamily. ABCC10 mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs. The ABCC10 transporter is a 171-kDa protein that is localized on the basolateral cell membrane. ABCC10 is a broad-specificity transporter of xenobiotics, including antitumor drugs, such as taxanes, epothilone B, vinca alkaloids, and cytarabine, as well as modulators of the estrogen pathway, such as tamoxifen. In recent years, ABCC10 inhibitors, including cepharanthine, lapatinib, erlotinib, nilotinib, imatinib, sildenafil, and vardenafil, have been reported to overcome ABCC10-mediated MDR. This review discusses some recent and clinically relevant aspects of the ABCC10 drug efflux transporter from the perspective of current chemotherapy, particularly its inhibition by tyrosine kinase inhibitors and phosphodiesterase type 5 inhibitors.
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影响因子：
11.2
作者：
Dai CL;Tiwari AK;Wu CP;Su XD;Wang SR;Liu DG;Ashby CR Jr;Huang Y;Robey RW;Liang YJ;Chen LM;Shi CJ;Ambudkar SV;Chen ZS;Fu LW
通讯作者：
Fu LW
影响因子：
3.9
作者：
ElSharawy, Abdou;Hundrieser, Bernd;Hampe, Jochen
通讯作者：
Hampe, Jochen
影响因子：
3.6
作者：
Chen, ZS;Hopper-Borge, E;Kruh, GD
通讯作者：
Kruh, GD
影响因子：
1.5
作者：
Gatanaga, Hiroyuki;Tachikawa, Natsuo;Oka, Shinichi
通讯作者：
Oka, Shinichi
影响因子：
1.8
作者：
Bleasby, K.;Castle, J. C.;Slatter, J. G.
通讯作者：
Slatter, J. G.