Chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in C57BL/6J mice
Chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in C57BL/6J mice
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DOI：
10.1016/s0021-9150(00)00758-9
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发表时间：
2001-09-01
期刊：
影响因子：
5.3
通讯作者：
Kuo, CC
中科院分区：
文献类型：
--
作者：
Blessing, E;Campbell, LA;Kuo, CC
肺炎衣原体感染和心血管疾病之间的关联已经出现了相当多的证据。使用转基因小鼠和高胆固醇血症兔的动物模型显示了C.肺炎链球菌在加速动脉粥样硬化斑块发展中的作用。在本研究中，我们评估了慢性C。肺炎杆菌感染对C57 BL/6 J小鼠动脉粥样硬化的影响，喂食常规食物饮食或高脂肪、高胆固醇饮食。在18周时，与对照组小鼠相比，食用致动脉粥样硬化饮食的感染动物的病变面积明显更大（增加2.5倍; 4177 +/- 777 vs. 1650 +/- 808 mum（2）; P < 0.05）和24周龄（增加3.3倍; 14139 +/- 4147对4298 +/- 869 μ m（2）; P < 0.02）。本研究表明，慢性C。肺炎克雷伯氏菌感染加速饮食诱导的高胆固醇血症小鼠动脉粥样硬化病变的发展，表明C.肺炎是动脉粥样硬化形成中高脂血症的共同危险因素。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Considerable evidence of an association between Chlamydia pneumoniae infections and cardiovascular disease has emerged. Animal models using genetically altered mice and hypercholesterolemic rabbits have shown a pathogenic role of C. pneumoniae in accelerating atherosclerotic plaque development. In the present study, we evaluated the effect of chronic C. pneumoniae infection on atherosclerosis in C57BL/6J mice, fed either a regular chow diet or a high fat, high cholesterol diet. Infected animals on an atherogenic diet developed significantly larger lesion areas compared with control mice at 18 weeks (2.5-fold increase; 4177 +/- 777 vs. 1650 +/- 808 mum(2); P < 0.05) and 24 weeks of age (3.3-fold increase; 14139 +/- 4147 vs. 4298 +/- 869 mum(2); P < 0.02). This study shows that chronic C. pneumoniae infection accelerates atherosclerotic lesion development in diet induced hypercholesterolemic mice, indicating that C. pneumoniae is a co-risk factor of hyperlipidemia in atherogenesis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.