Step emulsification in microfluidic droplet generation: mechanisms and structures
Step emulsification in microfluidic droplet generation: mechanisms and structures
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DOI：
10.1039/d0cc03628e
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发表时间：
2020-08-18
影响因子：
4.9
通讯作者：
Li, Dachao
中科院分区：
文献类型：
--
作者：
Shi, Zhi;Lai, Xiaochen;Li, Dachao
基于液滴的微流控技术已广泛应用于功能材料合成和生物医学信息测量，其中分步乳化作为一个集成系统结合了单分散液滴形成的均匀性和通量的优点。本文综述了分步乳化的机理和经典结构。在液滴形成机制方面，我们描述了与微通道几何形状相关的液滴尺寸和分离制度。以液滴的形成为特征，分别介绍了界面张力驱动的微流控分步乳化和浮力驱动的离心分步乳化，以及它们为提高液滴均匀性和通量而进行的结构改进。最后，对分步乳化技术在机理、制备和应用方面的发展进行了展望。
The droplet-based microfluidic techniques have been applied widely in functional material synthesis and biomedical information measurements, wherein step emulsification as an integrated system combines the advantages of homogeneity and throughput in monodisperse droplet formation. This paper reviews the mechanisms and classical structures of step emulsification. In terms of droplet formation mechanisms, we describe the droplet size and detachment regimes related to the microchannel geometry. Distinguished by droplet formation, microfluidic step emulsification driven by interfacial tension and centrifugal step emulsification related to buoyancy are introduced respectively, including their improved structures for enhancing the droplet homogeneity and throughput. Finally, the perspectives about the developments of step emulsification in mechanisms, fabrications, and applications are discussed.