Green tea polyphenolic antioxidants and skin photoprotection (Review).
Green tea polyphenolic antioxidants and skin photoprotection (Review).
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DOI：
10.3892/ijo.18.6.1307
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发表时间：
2001-06
影响因子：
5.2
通讯作者：
S. Katiyar;C. Elmets
中科院分区：
文献类型：
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作者：
S. Katiyar;C. Elmets
绿茶在世界范围内作为一种流行的饮料被消费，特别是在中国、韩国、日本和印度等亚洲国家。它含有多酚化合物，也称为表儿茶素，本质上是抗氧化剂。许多实验室已经表明，在不同的动物模型中，局部治疗或口服绿茶多酚可以抑制化学致癌物或紫外线辐射诱发的皮肤肿瘤发生。研究表明，绿茶提取物还具有抗炎活性。绿茶的这些抗炎和抗癌特性归因于其中存在的多酚成分。绿茶中负责这些生化或药理作用的主要且最具化学预防作用的成分是 (-)-表没食子儿茶素-3-没食子酸酯 (EGCG)。了解绿茶这些作用的分子机制是许多实验室研究的主题。绿茶多酚对皮肤的治疗已被证明可以调节涉及炎症反应、细胞增殖和化学肿瘤促进剂反应以及紫外线 (UV) 光诱导的皮肤炎症炎症标志物的生化途径。对小鼠皮肤进行 EGCG 局部治疗还可以预防 UVB 引起的免疫抑制和氧化应激。绿茶治疗对人体皮肤（无论是局部还是口服）对紫外线引起的炎症或致癌反应的保护作用尚不清楚。根据有记录的绿茶对小鼠皮肤模型的广泛有益作用，而对人类皮肤的有益作用却很少，许多制药和化妆品公司正在用绿茶提取物补充其护肤产品。因此，本次交流的重点是回顾和分析绿茶多酚对皮肤的光保护作用。
Green tea is consumed as a popular beverage worldwide particularly in Asian countries like China, Korea, Japan and India. It contains polyphenolic compounds also known as epicatechins, which are antioxidant in nature. Many laboratories have shown that topical treatment or oral consumption of green tea polyphenols inhibits chemical carcinogen- or ultraviolet radiation-induced skin tumorigenesis in different animal models. Studies have shown that green tea extract also possesses anti-inflammatory activity. These anti-inflammatory and anti-carcinogenic properties of green tea are due to their polyphenolic constituents present therein. The major and most chemopreventive constituent in green tea responsible for these biochemical or pharmacological effects is (-)-epigallocatechin-3-gallate (EGCG). Understanding the molecular mechanisms of these effects of green tea is a subject of investigation in many laboratories. Treatment of green tea polyphenols to skin has been shown to modulate the biochemical pathways involved in inflammatory responses, cell proliferation and responses of chemical tumor promoters as well as ultraviolet (UV) light-induced inflammatory markers of skin inflammation. Topical treatment with EGCG on mouse skin also results in prevention of UVB-induced immunosuppression, and oxidative stress. The protective effects of green tea treatment on human skin either topically or consumed orally against UV light-induced inflammatory or carcinogenic responses are not well understood. Based on documented extensive beneficial effects of green tea on mouse skin models and very little in human skin, many pharmaceutical and cosmetic companies are supplementing their skin care products with green tea extracts. Therefore, the focus of this communication is to review and analyze the photoprotective effects of green tea polyphenols to skin.