microRNA and thyroid hormone signaling in cardiac and skeletal muscle.
microRNA and thyroid hormone signaling in cardiac and skeletal muscle.
复制标题
心肌和骨骼肌中的 microRNA 和甲状腺激素信号传导
DOI：
10.1186/s13578-017-0141-y
复制
发表时间：
2017
影响因子：
7.5
通讯作者：
Ying H
中科院分区：
文献类型：
--
作者：
Zhang D;Li Y;Liu S;Wang YC;Guo F;Zhai Q;Jiang J;Ying H
甲状腺激素 (TH) 信号传导在所有器官或组织（包括心脏和骨骼肌）的分化、生长、代谢和生理功能中发挥着关键作用。由于我们对 TH 作用分子机制的理解取得了重大进展，人们普遍认为 TH 信号在多个层面上受到调节。越来越多的发现表明 microRNA (miRNA) 可以作为基因表达的微调调节因子，并为信号通路添加复杂的调节层。最近，一些针对心脏和骨骼肌的开创性研究证明了 miRNA 和 TH 信号传导之间的相互作用，表明 miRNA 可能介导和/或调节 TH 信号传导。这篇综述介绍了涉及 miRNA 和 TH 信号传导之间串扰的最新进展，以及显示 miRNA 在 TH 信号传导中重要性的当前证据，特别强调了心肌和骨骼肌中肌肉特异性 miRNA (myomiRs) 的研究。虽然 miRNA 和 TH 信号传导相互调节的研究还处于起步阶段，但它已经有助于我们目前对 TH 作用和 miRNA 生物学的理解。我们还鼓励进一步研究解决生理和病理条件下 miRNA 在 TH 信号传导中的相对贡献，以及一组 miRNA 如何协调整合到 TH 复杂的分层调控网络中。
Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant progress in our understanding of the molecular mechanisms that underlie TH action, it’s widely accepted that TH signaling is regulated at multiple levels. A growing number of discoveries suggest that microRNAs (miRNAs) act as fine-tune regulators of gene expression and adds sophisticated regulatory tiers to signaling pathways. Recently, some pioneering studies in cardiac and skeletal muscle demonstrating the interplay between miRNAs and TH signaling suggest that miRNAs might mediate and/or modulate TH signaling. This review presents recent advances involving the crosstalk between miRNAs and TH signaling and current evidence showing the importance of miRNA in TH signaling with particular emphasis on the study of muscle-specific miRNAs (myomiRs) in cardiac and skeletal muscle. Although the research of the reciprocal regulation of miRNAs and TH signaling is only at the beginning stage, it has already contributed to our current understanding of both TH action and miRNA biology. We also encourage further investigations to address the relative contributions of miRNAs in TH signaling under physiological and pathological conditions and how a group of miRNAs are coordinated to integrate into the complex hierarchical regulatory network of TH.