Post-COVID-19 pneumonia lung fibrosis: a worrisome sequelae in surviving patients
Post-COVID-19 pneumonia lung fibrosis: a worrisome sequelae in surviving patients
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DOI：
10.1186/s43055-021-00484-3
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发表时间：
2021-04-13
期刊：
影响因子：
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通讯作者：
Ghonimy MB
中科院分区：
文献类型：
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作者：
Ali RM;Ghonimy MB
进行性纤维化肺病是COVID-19肺炎的可能后果之一，也是最令人担忧的长期并发症之一。肺纤维化与不可逆转的肺功能障碍有关。既往COVID-19感染的长期肺部变化尚未完全了解，应纳入进一步的研究。本研究的目的是早期发现和预测可能出现严重并发症的患者，从而为早期引入抗纤维化药物提供机会。对2020年4月至12月在埃及开罗有临床表现并经PCR确诊的80例新冠肺炎患者进行随访MDCT评估。对CT图像进行分析，并与随访资料（不同放射学征象和残余纤维化改变）进行对比研究。虽然covid -19后肺纤维化没有明确的病因，但有一些预测因素，如年龄大、吸烟、CT严重程度评分高、长期机械通气等。早期发现潜在的covid -19后肺纤维化病例可能有机会预防或至少改变这种致残性并发症。
Progressive fibrotic lung disease is one of the possible consequences of COVID-19 pulmonary pneumonia, and it is one of the most worrying long-term complications. Pulmonary fibrosis is associated with non-reversible lung dysfunction. The long-term lung changes of previous COVID-19 infection still not completely understood and should be included in further studies. The aim of this study is the early detection and prediction of patients whom may develop such serious complication, thus giving a chance for early introduction of anti-fibrotic drugs. From April 2020 to December 2020, 80 patients in Cairo, Egypt, who have clinical manifestations and confirmed COVID-19 by PCR, were evaluated by follow-up MDCT. CT image analysis was processed including comparative study using follow-up data (different radiological signs and residual fibrotic changes). Although there was no specific cause for post-COVID-19 lung fibrosis, there were some predicting factors such as old age, cigarette smoking, high CT severity score, and long-term mechanical ventilation. Early detection of potential cases of post-COVID-19 pulmonary fibrosis may give a chance to prevent or at least modify such disabling complication.