Effects of adrenomedullin 2 on regional hemodynamics in conscious rats
Effects of adrenomedullin 2 on regional hemodynamics in conscious rats
复制标题
DOI：
10.1016/j.ejphar.2006.11.043
复制
发表时间：
2007-03-06
影响因子：
5
通讯作者：
Abe, Youichi
中科院分区：
文献类型：
--
作者：
Fujisawa, Yoshihide;Nagai, Yukiko;Abe, Youichi
本研究旨在评估大鼠肾上腺髓质素2对清醒Wistar京都（WKY）大鼠和自发性高血压大鼠（SHR）全身和局部血流动力学的影响。静脉输注大鼠肾上腺髓质素2（0.25-5 μ g/kg/min）可降低血压，并以剂量依赖性方式增加两种类型大鼠的心率。大鼠肾上腺髓质素2（5 μ g/kg/min）增加心率和心输出量。结果，总外周阻力显著降低。在SHR中，肾上腺髓质素2显著增加心脏、肝脏、脾脏、肾脏和肾上腺的局部血流量。特别是对心脏、肝脏和肾脏的影响显著。在WKY大鼠中再现了局部血流动力学变化，并且SHR和WKY大鼠之间对大鼠肾上腺髓质素2的局部反应没有质的差异。因此，大鼠肾上腺髓质素2主要增加血流速度的器官，丰富的血液供应的心输出量。大鼠肾上腺髓质素2可能有助于调节心血管系统，作为一种局部血管舒张激素以及循环激素。(c)2006 Elsevier B. V.保留所有权利。
The present study aimed to assess the effects of rat adrenomedullin 2 on systemic and regional hemodynamics in conscious Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). Intravenous infusion of rat adrenomedullin 2 (0.25-5 mu g/kg/min) decreased blood pressure, and increased heart rate in a dose-dependent manner in both types of rats. Rat adrenomedullin 2 (5 mu g/kg/min) increased heart rate and cardiac output. As a result, total peripheral resistance significantly decreased. In SHRs, adrenomedullin 2 significantly increased regional blood flow in the heart, liver, spleen, kidneys, and adrenal glands. Especially, effects on heart, liver, and kidneys were remarkable. Regional hemodynamic changes were reproduced in WKY rats, and there was no qualitative difference in regional responses to rat adrenomedullin 2 between SHRs and WKY rats. Thus, rat adrenomedullin 2 predominantly increased flow rates in organs that were richly blood-supplied from cardiac output. Rat adrenomedullin 2 may contribute to the regulation of the cardiovascular system, by acting as a local vasodilatory hormone as well as a circulatory hormone. (c) 2006 Elsevier B.V. All rights reserved.