Latent class analysis of a heterogeneous international sample of patients with myalgic encephalomyelitis/chronic fatigue syndrome
Latent class analysis of a heterogeneous international sample of patients with myalgic encephalomyelitis/chronic fatigue syndrome
复制标题
DOI：
10.1080/21641846.2018.1494530
复制
发表时间：
2018-01-01
影响因子：
2.8
通讯作者：
Jason, Leonard A.
中科院分区：
文献类型：
--
作者：
Huber, Kayla A.;Sunnquist, Madison;Jason, Leonard A.
背景：肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）患者通常在症状学、病程、发病、持续时间和功能残疾方面表现出差异。鉴于这种多样性，以前的工作试图确定基于症状的ME/CFS亚型。然而，结果并不一致。目的：本研究旨在阐明ME/CFS的潜在亚型，并探讨亚型成员对健康功能的影响。方法：12种非核心（即较少被认可）症状被纳入1210名ME/CFS成人的潜在分类分析。用多项逻辑回归评估班级成员的人口统计学和疾病相关预测因子。然后进行方差分析，以确定在简短健康调查（SF-36）的八个子量表上是否存在班级间的显著差异。结果：选择了六类解决方案，其中一类可能支持所有非核心症状，一类不太可能支持任何非核心症状，四类可能支持一个或两个非核心症状域（即循环/神经内分泌障碍，直立不耐受和胃肠道窘迫）。SF-36的所有子量表都存在显著的班级功能差异。结论：这些结果提示了ME/CFS的亚型，如果重复，可能有助于医生为患者提供量身定制的治疗，并允许研究人员形成更均匀的样本。
Background: Individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) routinely display differences in symptomatology, as well as illness course, onset, duration, and functional disability. Given such diversity, previous work has attempted to identify symptom-based ME/CFS subtypes. However, results have been inconsistent.Purpose: This study sought to elucidate potential subtypes of ME/CFS as well as explore the impact of subtype membership on health functioning.Methods: Twelve non-core (i.e. less frequently endorsed) symptoms were included in a latent class analysis of 1,210 adults with ME/CFS. Demographic and illness-related predictors of class membership were evaluated with a multinomial logistic regression. ANOVAs were then performed to determine if there were significant differences across class on the eight subscales of the Short-Form Health Survey (SF-36).Results: A six-class solution was selected, which consisted of one class that was likely to endorse all non-core symptoms, one class that was unlikely to endorse any non-core symptoms, and four classes that were likely to endorse either one or two non-core symptom domains (i.e. circulatory/neuroendocrine impairment, orthostatic intolerance, and gastro-intestinal distress). Significant functioning differences by class were present for all SF-36 subscales.Conclusions: These results are suggestive of subtypes of ME/CFS and, if replicated, may assist physicians in providing tailored treatment to patients and allow researchers to form more homogeneous samples.