Evidence against Vitamin K Deficiency in Normal Neonates
Evidence against Vitamin K Deficiency in Normal Neonates
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正常新生儿缺乏维生素 K 的证据
DOI：
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发表时间：
1980
影响因子：
6.7
通讯作者：
V. Mitchell
中科院分区：
文献类型：
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作者：
R. Malia;F. Preston;V. Mitchell
对24例正常足月新生儿脐带血进行了研究。我们证实了先前描述的凝血酶原时间延长和维生素K依赖性凝血因子水平低（1），但使用许多最近开发的免疫学和凝血技术，我们没有发现维生素K缺乏的证据。我们的结论是，维生素K依赖性凝血因子的正常新生儿的水平下降的结果，减少合成的未成熟的肝脏，这是值得怀疑的维生素K预防是否是必要的，这些婴儿。
Summary Umbilical cord plasmas from 24 normal full-term neonates were studied. We confirmed the prolonged prothrombin time and low levels of Vitamin K dependent clotting factors previously described (1), but using a number of recently developed immunological and coagulation techniques we could find no evidence of vitamin K deficiency. We conclude that the decreased levels of vitamin K dependent clotting factors of normal neonates are the result of decreased synthesis by the immature liver and that it is questionable whether vitamin K prophylaxis is necessary for these infants.