The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy.
The Mutual Interaction Between Sleep and Epilepsy on the Neurobiological Basis and Therapy.
复制标题
睡眠与癫痫的相互影响的神经生物学基础和治疗
DOI：
10.2174/1570159x15666170509101237
复制
发表时间：
2018
影响因子：
5.3
通讯作者：
Huang ZL
中科院分区：
文献类型：
--
作者：
Wang YQ;Zhang MQ;Li R;Qu WM;Huang ZL
睡眠和癫痫以复杂的双向方式相互关联。然而，我们对这种关系的理解仍然不清楚。有关睡眠与癫痫相互作用的神经生物学基础的文献表明，非快动眼睡眠与特发性全身性癫痫有着共同的丘脑皮质网络。大多数神经递质和神经调质如腺苷、褪黑激素、前列腺素D2、5-羟色胺和组胺被发现调节睡眠-觉醒行为，并且也被认为具有抗癫痫作用;抗癫痫药物反过来也对睡眠有影响。此外，许多调节睡眠-觉醒周期的药物也可以作为潜在的抗癫痫药物。癫痫的非药物治疗包括生酮饮食、癫痫手术、神经刺激等也会影响睡眠。在本文中，我们解决了这些现象中涉及的问题，并讨论了用于修改它们的各种疗法。
Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our under-standing of this relationship remains unclear. The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Most of neurotransmitters and neuromodulators such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine are found to regulate the sleep-wake behavior and also considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep. Fur-thermore, many drugs that regulate the sleep-wake cycle can also serve as potential antiseizure agents. The nonpharmacologi-cal management of epilepsy including ketogenic diet, epilepsy surgery, neurostimulation can also influence sleep. In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them.