Dissociation between Controlled and Automatic Processes in the Behavioral Variant of Fronto-Temporal Dementia
Dissociation between Controlled and Automatic Processes in the Behavioral Variant of Fronto-Temporal Dementia
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DOI：
10.3233/jad-2010-100042
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发表时间：
2010-01-01
影响因子：
4
通讯作者：
Salmon, Eric
中科院分区：
文献类型：
--
作者：
Collette, Fabienne;Van der Linden, Martial;Salmon, Eric
额颞性痴呆患者的认知功能下降影响到几个认知域，这是经常被报道的。我们感兴趣的是，通过使用一种专门开发的评估工具来探索自动过程和受控过程之间的区别，即Jacoby开发的过程分离程序(PDP)，来确定这些缺陷是否可以被解释为反映受控认知过程的损害。PDP被应用于词干完成任务，以确定自动和控制过程对情景记忆成绩的贡献，并被用于12例行为变异额颞叶痴呆(BV-FTD)患者和20名对照组(CS)。BV-FTD患者在控制过程的估计上的表现低于CS，但在自动过程的估计上没有观察到组间差异。受控过程和自动过程估计的组间比较显示，在BV-FTD中，自动化过程对绩效的贡献较大，而受控过程对BV-FTD的贡献略大一些。这些结果清楚地表明了BV-FTD受控记忆过程的改变。
A decline of cognitive functioning affecting several cognitive domains was frequently reported in patients with frontotemporal dementia. We were interested in determining if these deficits can be interpreted as reflecting an impairment of controlled cognitive processes by using an assessment tool specifically developed to explore the distinction between automatic and controlled processes, namely the process dissociation procedure (PDP) developed by Jacoby [1]. The PDP was applied to a word stem completion task to determine the contribution of automatic and controlled processes to episodic memory performance and was administered to a group of 12 patients with the behavioral variant of frontotemporal dementia (bv-FTD) and 20 control subjects (CS). Bv-FTD patients obtained a lower performance than CS for the estimates of controlled processes, but no group differences was observed for estimates of automatic processes. The between-groups comparison of the estimates of controlled and automatic processes showed a larger contribution of automatic processes to performance in bv-FTD, while a slightly more important contribution of controlled processes was observed in control subjects. These results are clearly indicative of an alteration of controlled memory processes in bv-FTD.