Low-dose aspirin use does not improve in vitro fertilization outcomes in poor responders
Low-dose aspirin use does not improve in vitro fertilization outcomes in poor responders
复制标题
DOI：
10.1016/j.fertnstert.2007.05.007
复制
发表时间：
2008-05-01
影响因子：
6.7
通讯作者：
Scott, Richard T., Jr.
中科院分区：
文献类型：
--
作者：
Frattarelli, John L.;McWilliams, Grant D. E.;Scott, Richard T., Jr.
目的：评估阿司匹林是否能改善诊断为低反应的体外受精（IVF）患者的妊娠结局。设计：回顾性队列分析。设置：学术私人诊所。患者：1250例接受IVF的低反应患者。干预：IVF周期前和周期中使用低剂量（81 mg）阿司匹林。主要结局指标：活产率。结果：服用81 mg阿司匹林的患者基础窦卵泡计数在统计学上显著更高，刺激天数更多，使用的促性腺激素安瓿更多，雌二醇峰值水平更高，在人绒毛膜促性腺激素给药当天直径>= 14 mm的卵泡更多。服用阿司匹林的患者总体受精率下降。IVF结局率（植入、妊娠、流产或活产）无差异。结论：诊断为反应不良的患者接受81 mg阿司匹林治疗后，许多IVF刺激参数增加，受精率降低。在IVF结局率方面没有发现81 mg阿司匹林摄入量的改善。
Objective: To assess if aspirin improves pregnancy outcome in patients undergoing in vitro fertilization (IVF) with a diagnosis of poor response.Design: Retrospective cohort analysis.Setting: Academic private practice.Patient(s): 1250 poor-responder patients undergoing IVF.Intervention(S): Low-dose (81 mg) aspirin before and during an IVF cycle.Main Outcome Measure(S): Live-birth rate.Result(s): Patients taking 81 mg of aspirin had statistically significantly higher basal antral follicle counts, more days of stimulation, more ampules of gonadotropins used, higher peak estradiol levels, and more follicles that were >= 14 mm in diameter on the day of human chorionic gonadotropin administration. There was a decrease in the overall fertilization rate for the patients taking aspirin. There was no difference in IVF outcome rates (implantation, pregnancy, loss, or live birth).Conclusion(s): Patients with a diagnosis of poor response who were taking a regimen of 81 of mg aspirin showed an increase in many IVF stimulation parameters and a decrease in fertilization rates. No improvement secondary to 81-mg aspirin intake was found in IVF outcome rates.