LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms.
LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms.
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DOI：
10.3390/ijms21228855
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发表时间：
2020-11-23
影响因子：
5.6
通讯作者：
Kushlinskii NE
中科院分区：
文献类型：
--
作者：
Braga EA;Fridman MV;Moscovtsev AA;Filippova EA;Dmitriev AA;Kushlinskii NE
卵巢癌（OvCa）无症状地发展，直到其达到具有转移、化学抗性和不良预后的晚期阶段。我们的综述主要集中在OvCa的竞争性内源性RNA（ceRNA）的模型下，与蛋白质编码的mRNA竞争结合的调节性长非编码RNA（lncRNA）的分析。对出版物的分析表明，大多数lncRNA作为ceRNA参与OvCa进展：迁移、侵袭、上皮-间质转化（EMT）和转移。超过30种lncRNA被证明是OvCa患者生存和/或对治疗反应的预测因子。对于许多致癌（CCAT 1、HOTAIR、NEAT 1和TUG 1等）和一些抑制性lncRNA，鉴定了几个lncRNA/miRNA/mRNA轴，这揭示了它们中的每一个的各种功能。我们的综述还考虑了lncRNA除了作为ceRNA之外的替代作用机制的例子，包括直接与mRNA或蛋白质结合，其中一些（DANCR，GAS 5，MALAT 1和UCA 1等）根据靶蛋白通过两种机制起作用。基于来自文献和Panther或KEGG（京都基因和基因组百科全书）数据库的数据的系统分析显示，lncRNA的显著部分影响OvCa转移、EMT和化学抗性中涉及的关键途径。
Ovarian cancer (OvCa) develops asymptomatically until it reaches the advanced stages with metastasis, chemoresistance, and poor prognosis. Our review focuses on the analysis of regulatory long non-coding RNAs (lncRNAs) competing with protein-coding mRNAs for binding to miRNAs according to the model of competitive endogenous RNA (ceRNA) in OvCa. Analysis of publications showed that most lncRNAs acting as ceRNAs participate in OvCa progression: migration, invasion, epithelial-mesenchymal transition (EMT), and metastasis. More than 30 lncRNAs turned out to be predictors of survival and/or response to therapy in patients with OvCa. For a number of oncogenic (CCAT1, HOTAIR, NEAT1, and TUG1 among others) and some suppressive lncRNAs, several lncRNA/miRNA/mRNA axes were identified, which revealed various functions for each of them. Our review also considers examples of alternative mechanisms of actions for lncRNAs besides being ceRNAs, including binding directly to mRNA or protein, and some of them (DANCR, GAS5, MALAT1, and UCA1 among others) act by both mechanisms depending on the target protein. A systematic analysis based on the data from literature and Panther or KEGG (Kyoto Encyclopedia of Genes and Genomes) databases showed that a significant part of lncRNAs affects the key pathways involved in OvCa metastasis, EMT, and chemoresistance.
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影响因子：
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