Clinical applications of a peptide-based vaccine for glioblastoma.
Clinical applications of a peptide-based vaccine for glioblastoma.
复制标题
胶质母细胞瘤肽疫苗的临床应用。
DOI：
10.1016/j.nec.2009.09.001
复制
发表时间：
2010
影响因子：
2.6
通讯作者：
Sampson,JohnH
中科院分区：
文献类型：
--
作者：
Kanaly,CharlesW;Ding,Dale;Heimberger,AmyB;Sampson,JohnH
多形性胶质母细胞瘤 (GBM) 是一种恶性、顽固性脑癌，尚无已知的治愈方法，标准疗法为开发更好、更有效的治疗方法留下了巨大的空间。免疫疗法是治疗实体瘤的一种有前途的方法，它引导患者自身的免疫系统破坏肿瘤细胞。迄今为止最广泛和最成功的基于免疫学的癌症治疗涉及单克隆抗体的被动给药，但主动疫苗接种策略和细胞转移疗法也产生了显着的抗肿瘤反应。本文总结了免疫系统的重要组成部分，讨论了中枢神经系统 (CNS) 免疫特权的具体困难，并回顾了正在尝试的各种治疗方法，重点是使用肽疫苗进行主动免疫治疗治疗 GBM。
Glioblastoma multiforme (GBM) is a malignant, relentless brain cancer with no known cure, and standard therapies leave significant room for the development of better, more effective treatments. Immunotherapy is a promising approach to the treatment of solid tumors that directs the patient’s own immune system to destroy tumor cells. The most widespread and successful immunologically-based cancer therapy to date involves the passive administration of monoclonal antibodies, but significant antitumor responses have also been generated with active vaccination strategies and cell-transfer therapies as well. This article summarizes the important components of the immune system, discusses the specific difficulty of immunologic privilege in the central nervous system (CNS), and reviews the variety of treatment approaches that are being attempted, with an emphasis on active immunotherapy using peptide vaccines in the treatment of GBM.