Novel insights into a major DNA oxidative lesion: its effects on Z-DNA stabilization.

Novel insights into a major DNA oxidative lesion: its effects on Z-DNA stabilization.
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DOI:
10.1039/c5ob01340b
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发表时间:
2015-08
影响因子:
3.2
通讯作者:
Jia-Qi Wang;Shaoru Wang;Cheng Zhong;Tian Tian-Tian;Xiang Zhou
Jia-Qi Wang;Shaoru Wang;Cheng Zhong;Tian Tian-Tian;Xiang Zhou
中科院分区:
化学3区
文献类型:
--
作者:
Jia-Qi Wang;Shaoru Wang;Cheng Zhong;Tian Tian-Tian;Xiang Zhou

文献摘要

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在这里,我们提供了新的见解8-oxodG取代对CpG二核苷酸DNA的B-Z转换的影响。不同技术的组合,包括CD研究,PAGE分析,DFT计算和分子建模已被共同使用。
Here, we have provided novel insights into the effects of 8-oxodG substitutions on B-Z transitions of CpG dinucleotide DNAs. A combination of different techniques including a CD study, a PAGE analysis, DFT calculations and molecular modeling has been collectively used.