RIPENING OF THE UTERINE CERVIX OF THE GUINEA-PIG AFTER TREATMENT WITH THE PROGESTERONE ANTAGONIST ONAPRISTONE (ZK-98.299) - AN ELECTRON-MICROSCOPIC STUDY
RIPENING OF THE UTERINE CERVIX OF THE GUINEA-PIG AFTER TREATMENT WITH THE PROGESTERONE ANTAGONIST ONAPRISTONE (ZK-98.299) - AN ELECTRON-MICROSCOPIC STUDY
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DOI：
10.1093/oxfordjournals.humrep.a136909
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发表时间：
1989-05-01
影响因子：
6.1
通讯作者：
ELGER, W
中科院分区：
文献类型：
--
作者：
HEGELEHARTUNG, C;CHWALISZ, K;ELGER, W
在豚鼠妊娠晚期，通过电子显微镜检查研究了孕酮拮抗剂（AG，即奥那司酮ZK 98.299）对子宫颈的影响。用AG治疗导致胶原纤维溶解、分裂和解离，以及由于水肿而使纤维间间隙扩大。这与多形核粒细胞、巨噬细胞和肥大细胞数量增加以及高度活跃的成纤维细胞的出现有关。讨论了这些细胞在胶原纤维解离中的可能作用。将AG诱导的子宫颈显著变化与未治疗的豚鼠足月妊娠时子宫颈成熟的形态学特征进行比较，未观察到显著差异。这表明AG以一种生理方式导致子宫颈成熟和扩张，并且在经过慎重的毒理学筛选之后，可能是一种对产科适应证极为有用的药物。
The effects of the progesterone antagonist (AG) onapristone ZK 98.299 on the uterine cervix were investigated by electron microscopic examination in guinea-pigs during late pregnancy. Treatment with the AG led to dissolution, splitting up and dissociation of collagen fibres as well as expansion of the inter-fibrillar spaces due to oedema. This was associated with an increased number of polymorphonuclear granulocytes, macrophages and mast cells as well as with the appearance of highly active fibroblasts. The possible roles of these cells in the dissociation of collagenous fibres are discussed. Comparing the AG-induced prominent transformation of the uterine cervix with the morphological signs characteristic of cervical ripening in untreated guinea-pigs at term pregnancy, no significant differences could be observed. This suggests that AG brings about ripening and dilatation of the cervix in a phisiological manner and may be, after thoughtful toxicological screening, an extremely useful agent for obstetrical indications.