POTENT SELECTIVE INHIBITORS OF PROTEIN KINASE-C
POTENT SELECTIVE INHIBITORS OF PROTEIN KINASE-C
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DOI：
10.1016/0014-5793(89)81494-2
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发表时间：
1989-12-18
期刊：
影响因子：
3.5
通讯作者：
WILKINSON, SE
中科院分区：
文献类型：
--
作者：
DAVIS, PD;HILL, CH;WILKINSON, SE
从微生物肉汤产品staurosporine和K252a提供的结构铅中衍生出一系列有效的选择性蛋白激酶C抑制剂。我们的抑制剂阻断完整细胞（血小板和T细胞）中的PCK，并阻止单核细胞对白细胞介素2 （IL2）的增殖反应。
A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine and K252a. Our inhibitors block PCK in intact cells (platelets and T cells), and prevent the proliferation of mononuclear cells in response to interleukin 2 (IL2).