Amorphous or Crystalline? A Comparison of Particle Engineering Methods and Selection
Amorphous or Crystalline? A Comparison of Particle Engineering Methods and Selection
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DOI：
10.2174/1381612821666151008150457
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Smyth, Hugh D. C.
中科院分区：
文献类型：
--
作者：
Thakkar, Sachin G.;Fathe, Kristin;Smyth, Hugh D. C.
这篇综述旨在提供关于生产结晶和非晶态粒子的粒子工程的当前目标和技术的重要说明。本文讨论的技术包括传统结晶技术、超临界流体技术、喷雾干燥技术、可控溶剂结晶技术和超声结晶技术。还介绍了粒子工程方面的最新进展，包括液体喷雾冷冻、薄膜冷冻干燥、打印技术。该文件还审查了这些技术在其表征方法方面的优点和局限性。此外，还提供了一节讨论创建非晶态和晶态制剂方法在生物利用度和制剂中的效用的部分。
This review is intended to provide a critical account of the current goals and technologies of particle engineering regarding the production of crystalline and amorphous particles. The technologies discussed here cover traditional crystallization technologies, supercritical fluid technologies, spray drying, controlled solvent crystallization, and sonocrystallization. Also recent advancements in particle engineering including spray freezing into liquid, thin-film freeze-drying, PRINT technology are presented. The paper also examines the merits and limitations of these technologies with respect to their methods of characterization. Additionally a section discussing the utility of creating amorphous and crystalline formulation approaches in regards to bioavailability and utility in formulation is presented.