Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18.
Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18.
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DOI：
10.1001/archpsyc.1985.01790280019002
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发表时间：
1985-05
影响因子：
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通讯作者：
L. Baxter;M. Phelps;J. Mazziotta;Jeffrey M. Schwartz;R. Gerner;C. Selin;R. Sumida
中科院分区：
文献类型：
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作者：
L. Baxter;M. Phelps;J. Mazziotta;Jeffrey M. Schwartz;R. Gerner;C. Selin;R. Sumida
使用正电子发射断层扫描和氟脱氧葡萄糖F 18检查了单相抑郁症（N = 11）、双相抑郁症（N = 5）、躁狂症（N = 5）、双相混合状态（N = 3）患者和正常对照组（N = 9）的脑葡萄糖代谢率。所有受试者均在环境室内条件下仰卧并睁眼进行研究。双相抑郁和混合型患者幕上全脑葡萄糖代谢率显著低于其他对照组。双相抑郁症患者的全脑代谢率从抑郁或混合状态增加到心境正常或躁狂状态。与正常对照组和双相抑郁症患者相比，单相抑郁症患者的尾状核代谢率（除以整个半球的代谢率）显著降低。
Cerebral metabolic rates for glucose were examined in patients with unipolar depression (N = 11), bipolar depression (N = 5), mania (N = 5), bipolar mixed states (N = 3), and in normal controls (N = 9) using positron emission tomography and fluorodeoxyglucose F 18. All subjects were studied supine under ambient room conditions with eyes open. Bipolar depressed and mixed patients had supratentorial whole brain glucose metabolic rates that were significantly lower than those of the other comparison groups. The whole brain metabolic rates for patients with bipolar depression increased going from depression or a mixed state to a euthymic or manic state. Patients with unipolar depression showed a significantly lower ratio of the metabolic rate of the caudate nucleus, divided by that of the hemisphere as a whole, when compared with normal controls and patients with bipolar depression.