A shape-persistent D,L-dipeptide building block for the assembly of rigidified oligopeptides.
A shape-persistent D,L-dipeptide building block for the assembly of rigidified oligopeptides.
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用于组装刚性寡肽的形状持久的 D,L-二肽结构单元。
DOI：
10.1039/b613172g
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发表时间：
2006
影响因子：
3.2
通讯作者：
A. Geyer
中科院分区：
文献类型：
--
作者：
R. Hörger;A. Geyer
将甘露糖醛酸（5）转化为密集官能化的D，L-二肽模拟物1，随后插入环状六肽3中。与先前描述的L，L-二肽模拟物2相比，gulo构型的七元内酰胺1表现出倒置的环构象。尽管存在这种显著差异，但两者都偏好环状六肽内β转角的相同i至i + 1位置。
Mannuronic acid (5) was transformed into the densely functionalised D,L-dipeptide mimic 1 and subsequently inserted into the cyclic hexapeptide 3. The gulo-configurated seven-membered lactam 1 exhibits an inverted ring conformation compared to the previously described L,L-dipeptide mimic 2. In spite of this considerable difference, both prefer the same i to i + 1 positions of a beta-turn within a cyclic hexapeptide.