The nuclear receptor PXR: A master regulator of "Homeland" Defense
The nuclear receptor PXR: A master regulator of "Homeland" Defense
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DOI：
10.1615/critreveukaryotgeneexpr.v12.i1.30
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发表时间：
2002-01-01
影响因子：
1.6
通讯作者：
Forman, BM
中科院分区：
文献类型：
--
作者：
Dussault, I;Forman, BM
人类不断接触食品和环境中存在的有毒化学物质。我们还面临着体内化学反应有毒副产品的挑战。这些毒素需要被灭活或排出体外以维持体内平衡。孕烷 X 受体 (PXR) 是一种混杂的核受体，可被多种内源性和外源性毒素激活。激活后，PXR 会调节许多靶基因，这些基因涉及两个关键靶组织（肝脏和肠道）中的药物代谢和外排。在本文中，我们回顾了过去几年积累的数据，将 PXR 确定为这些途径整合的核心参与者。
Human beings are constantly exposed to toxic chemicals present in food and the environment. We are also challenged by toxic byproducts of chemical reactions within our own bodies. These toxins need to be inactivated or excreted to maintain homeostasis. Pregnane X receptor (PXR) is a promiscuous nuclear receptor that is activated by a diverse array of endogenous and exogenous toxins. On activation, PXR regulates a number of target genes involved in drug metabolism and efflux in two key target tissues: the liver and intestine. In this article, we review the data accumulated in the last few years identifying PXR as a central player in the integration of these pathways.