Number of persistent organic pollutants detected at high concentrations in a general population
Number of persistent organic pollutants detected at high concentrations in a general population
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DOI：
10.1016/j.envint.2012.02.005
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发表时间：
2012-09-01
影响因子：
11.8
通讯作者：
Gasull, Magda
中科院分区：
文献类型：
--
作者：
Porta, Miquel;Pumarega, Jose;Gasull, Magda
背景：对人类接触环境化学品的调查并未整合每人检测到的化合物数量和每种化合物的浓度。这就留下了未经测试的相关暴露场景，例如某些化合物浓度较低的个体是否具有高浓度的其他化合物。目的：分析高浓度下检测到的持久性有机污染物 (POP) 的数量。方法：通过气相色谱法和电子捕获检测技术，对西班牙加泰罗尼亚一般人群的代表性样本 (N = 919) 分析 19 种 POP 的血清浓度。结果：超过 58% 的参与者浓度处于 >= 的前四分之一八种最流行的 POP 中的 1 种，以及 >= 3 种 POP 中的 34%。 83% 的 60 至 74 岁女性的前四分之一中 POPs 浓度≥3； 56% 60 至 74 岁的女性患有 p,p'-DDE。 HCB 和 β-HCH 均位于各自的前四分位，其中 48% 的 POPs 浓度 >= 6 种位于前四分位。超过 30% 的受试者的浓度位于八种最常见 POP 中前十分之一的 1 至 5 种。一半人口的 1 至 5 种持久性有机污染物含量 >500 纳克/克。不到 4% 的人口中所有 8 种 POPs 均位于最低四分位数。结论：超过一半的研究人群的最高四分位数中存在 >= 1 种 POPs。人口中的重要子群体积累了高浓度的持久性有机污染物混合物。仅当单独观察每种化合物时，大多数人群中的 POP 浓度才显得较低。 (C) 2012 Elsevier Ltd. 保留所有权利。
Background: Surveys of human exposure to environmental chemicals do not integrate the number of compounds detected per person and the concentration of each compound. This leaves untested relevant exposure scenarios, such as whether individuals with low concentrations of some compounds have high concentrations of the other compounds.Objective: To analyze the number of persistent organic pollutants (POPs) detected at high concentrations.Methods: Serum concentrations of 19 POPs were analyzed by gas chromatography with electron-capture detection in a representative sample of the general population of Catalonia, Spain (N = 919).Results: Over 58% of participants had concentrations in the top quartile of >= 1 of the eight most prevalent POPs, and 34% of >= 3 POPs. 83% of women 60 to 74 years old had concentrations of >= 3 POPs in the top quartile; 56% of women 60 to 74 years had p,p'-DDE. HCB and beta-HCH all in their respective top quartiles, and 48% had concentrations of >= 6 POPs in the top quartile. Over 30% of subjects had concentrations in the top decile of 1 to 5 of the eight most prevalent POPs. Half of the population had levels of 1 to 5 POPs >500 ng/g. Less than 4% had all eight POPs in the lowest quartile.Conclusions: More than half of the study population had concentrations in the top quartile of >= 1 POPs. Significant subgroups of the population accumulate POP mixtures at high concentrations. POP concentrations appear low in most of the population only when each individual compound is looked at separately. (C) 2012 Elsevier Ltd. All rights reserved.