Expression, regulation and function of microRNAs in multiple sclerosis.
Expression, regulation and function of microRNAs in multiple sclerosis.
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多发性硬化症中 microRNA 的表达、调控和功能。
DOI：
10.7150/ijms.8647
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发表时间：
2014
影响因子：
3.6
通讯作者：
Nagarkatti P
中科院分区：
文献类型：
--
作者：
Ma X;Zhou J;Zhong Y;Jiang L;Mu P;Li Y;Singh N;Nagarkatti M;Nagarkatti P
MicroRNAs(MiRNAs)是19-25个核苷酸的单链RNAs，在转录后基因沉默中起着重要作用。已有研究表明，多发性硬化症(MS)患者的miRNAs表达异常。例如，miR-21、miR-142-3p、miR-146a、miR-146b、miR-155和miR-326在MS患者和小鼠模型的外周血单个核细胞(PBMC)和脑白质病变中表达上调。这些上调的miRNAs可作为MS的标志，并在MS的发病机制中发挥关键作用。此外，miR-15a、miR-19a、miR-22、miR-210和miR-223在调节性T细胞(Tregs)以及MS患者的血浆、血细胞、PBMC和脑白质组织中均上调，提示这些上调的miRNAs和Tregs可能在MS的发病机制中起作用。相反，其他miRNAs如miR-15a、miR-15b、miR-181c和miR-328在MS患者中表达下调，治疗MS的药物如干扰素-β和格列替拉默可能调节miRNA的表达，从而对MS患者有好处。MiR-155、miR-326等表达异常的miRNAs可作为MS的诊断标志物和治疗靶点。
MicroRNAs (miRNAs) are single-stranded 19-25 nucleotide-long RNAs and have an important role in post-transcriptional gene silencing. It has been demonstrated that miRNAs are dysregulated in patients with multiple sclerosis (MS). For instance, miR-21, miR-142-3p, miR-146a, miR-146b, miR-155 and miR-326 were up-regulated in both peripheral blood mononuclear cells (PBMCs) and brain white matter lesions from MS patients and mouse model as well. These up-regulated miRNAs may be used as a signature for MS and play critical roles in MS pathogenesis. Moreover, miR-15a, miR-19a, miR-22, miR-210 and miR-223 were up-regulated in both regulatory T cells (Tregs) and other samples such as plasma, blood cells, PBMCs and brain white matter tissues from MS patients, suggesting that these up-regulated miRNAs and Tregs may also play a role in MS pathogenesis. Contrarily, other miRNAs such as miR-15a, miR-15b, miR-181c and miR-328 were down-regulated in MS. Drugs such as interferon-β and glatiramer acetate for MS treatment may regulate miRNA expression and thus have benefits for MS patients. The dysregulated miRNAs such as miR-155 and miR-326 may be used as diagnostic markers and therapeutic targets for MS.
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影响因子：
30.5
作者：
Du, Changsheng;Liu, Chang;Pei, Gang
通讯作者：
Pei, Gang
多发性硬化症患者外周血中的干扰素β治疗过程中的microRNA表达变化。
影响因子：
5.6
作者：
Hecker M;Thamilarasan M;Koczan D;Schröder I;Flechtner K;Freiesleben S;Füllen G;Thiesen HJ;Zettl UK
通讯作者：
Zettl UK
影响因子：
3.3
作者：
De Santis, Giuseppe;Ferracin, Manuela;Granieri, Enrico
通讯作者：
Granieri, Enrico
影响因子：
5.8
作者：
Keller, Andreas;Leidinger, Petra;Ruprecht, Klemens
通讯作者：
Ruprecht, Klemens
影响因子：
2.2
作者：
Cetrulo Lorenzi, Julio Cesar;Brum, Doralina G.;Silva, Wilson Araujo, Jr.
通讯作者：
Silva, Wilson Araujo, Jr.