Exploring and exploiting plant cyclic peptides for drug discovery and development
Exploring and exploiting plant cyclic peptides for drug discovery and development
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DOI：
10.1002/med.21792
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发表时间：
2021-02-18
影响因子：
13.3
通讯作者：
Xu, Chengchao
中科院分区：
文献类型：
--
作者：
Zhang, Jingjing;Yuan, Jimin;Xu, Chengchao
自从胰岛素被发现以来，天然多肽已经成为治疗发展的重要资源。几十年的研究已经发现了一长串在临床上有广泛应用的多肽药物，从抗生素到高血压治疗再到止痛。这些美国FDA批准的多肽药物中有许多是从微生物和动物中提取的。相比之下，植物环肽作为治疗药物的巨大潜力在很大程度上仍未被发掘。这些大环肽通常具有刚性结构、良好的生物利用度和膜通透性，使其成为药物开发和工程的候选药物。本文介绍了植物环肽的三大类，并对其潜在的医学应用进行了综述。我们讨论了如何利用许多不同植物的基因组信息来快速搜索新的环肽，以及如何利用从它们的生物合成途径中获得的见解来改变生产和药物开发的过程。这些最新的进展为探索和利用植物环肽提供了一个新的角度，我们相信更多的植物来源的多肽药物即将问世。
Ever since the discovery of insulin, natural peptides have become an important resource for therapeutic development. Decades of research has led to the discovery of a long list of peptide drugs with broad applications in clinics, from antibiotics to hypertension treatment to pain management. Many of these US FDA-approved peptide drugs are derived from microorganisms and animals. By contrast, the great potential of plant cyclic peptides as therapeutics remains largely unexplored. These macrocyclic peptides typically have rigid structures, good bioavailability and membrane permeability, making them appealing candidates for drug development and engineering. In this review, we introduce the three major classes of plant cyclic peptides and summarize their potential medical applications. We discuss how we can leverage the genome information of many different plants to quickly search for new cyclic peptides and how we can take advantage of the insights gained from their biosynthetic pathways to transform the process of production and drug development. These recent developments have provided a new angle for exploring and exploiting plant cyclic peptides, and we believe that many more peptide drugs derived from plants are about to come.