CELL PROLIFERATION MIGRATION AND SPECIALIZATION IN EPITHELIUM OF MOUSE TONGUE
CELL PROLIFERATION MIGRATION AND SPECIALIZATION IN EPITHELIUM OF MOUSE TONGUE
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DOI：
10.1002/jez.1401630306
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发表时间：
1966-01-01
影响因子：
--
通讯作者：
CAMERON, IL
中科院分区：
文献类型：
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作者：
CAMERON, IL
本文报道了小鼠舌丝状乳头的三维结构。在丝状乳头区发现两种明显不同的角化细胞产物。两种细胞类型存在的证据是基于一系列的组织学，细胞学，显微操作和细胞迁移研究。对胚胎和成年小鼠舌头的研究表明，上皮基底层细胞中没有异质性的形态学证据，这支持了两种不同的角化细胞产物来源于同质细胞群的概念。氚标记胸苷放射自显影研究表明，上皮细胞的增殖池仅限于基底细胞层。该层的平均细胞更新率呈现为舌头的各个部分。还描述了祖细胞周期。研究表明，细胞从基底层到棘层的移动是时间上的随机事件，并且细胞移出基底层阻止了该细胞的进一步细胞增殖。结果表明，细胞出生时的位置机会决定了细胞是否会特化成两种不同的替代命运之一。在这种特定情况下，细胞的命运取决于细胞被迫占据的特定微环境。这种力是由细胞团的生长和随后对那些不能保持附着在基底膜上的细胞的挤出提供的。
The three dimensional structure of the filiform papilla of the mouse tongue is presented. Two distinctly different keratinized cell products are found in the region of the filiform papilla. Evidence for the existence of the two cell types is based on a series of histological, cytological, micro-manipulative and cell migration studies. A study of the tongues of embryonic and adult mice shows no morphological evidence of heterogenity in the cells of the basal layer of epithelium which supports the concept that the two different keratinized cell products derive from a homogeneous cell population. Tritiated thymidine autoradiographic studies reveal that the proliferative pool of epithelial cells is limited to the basal cell layer. The average cell renewal rate of this layer is presented for the various parts of the tongue. The progenitor cell cycle is also described. The studies indicate that the movement of a cell from the basal layer to the spinous layer is a random event in time and that the movement of a ceil out of the basal layer precludes further cell proliferation by that cell. The results indicate that it is positional chance at the time of cell birth which determines whether a cell will specialize into one of two different alternate fates. The fate of the cell in this particular case is based on the particular micro-environment the cell is forced to occupy. The force is provided by the growth of cellular mass and the subsequent crowding out of those cells not able to remain attached to the basement membrane.