Effects of cyanocobalamin on immunity in patients with pernicious anemia
Effects of cyanocobalamin on immunity in patients with pernicious anemia
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DOI：
10.1159/000112967
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Sonmez, Ahmet
中科院分区：
文献类型：
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作者：
Erkurt, Mehmet Ali;Aydogdu, Ismet;Sonmez, Ahmet
目的：探讨维生素B-12在恶性贫血中的作用。材料与方法：本研究于2002年4月至11月在Turgut Ozal医学中心血液科前瞻性进行。计算T和B淋巴细胞亚群表面抗原的绝对数量和比值、CD 4/CD 8比值，以评价白细胞和淋巴细胞数量的变化;还测量自然杀伤（NK）细胞计数、血清C3、C4和免疫球蛋白G、A和M水平，以评价维生素B-12对免疫的影响。将维生素B12治疗前的数值与网织红细胞计数峰值时的数值进行比较。结果如下：在维生素B-12缺乏患者中，发现CD 4+，尤其是CD 8+淋巴细胞的绝对数量减少; CD 4/CD 8比值增加，NK细胞活性降低。氰钴胺治疗后，淋巴细胞亚群的绝对数量和百分比升高。CD 4/CD 8比值升高和NK细胞活性降低得到恢复，C3、C4和免疫球蛋白水平升高。结论：这些研究结果表明，维生素B-12对细胞免疫具有重要的免疫调节作用，恶性贫血中免疫系统的异常可通过维生素B-12替代疗法恢复。版权所有（C）2008 S. Karger AG，巴塞尔。
Objective: The aim of the study was to evaluate the role of vitamin B-12 in patients with pernicious anemia. Materials and Methods: This study was conducted prospectively at the Turgut Ozal Medical Center, Department of Hematology, between April and November 2002. Absolute numbers and ratio of the surface antigens of T and B lymphocyte subgroups, CD4/CD8 ratio were calculated in order to evaluate changes in leukocyte and lymphocyte numbers; natural killer (NK) cell count, serum C3, C4, and levels of immunoglobulins G, A, and M were also measured to evaluate vitamin B-12 effect on immunity. Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count. Results: In vitamin B-12-deficient patients, absolute numbers of CD4+ and especially CD8+ lymphocytes were found to be decreased; CD4/CD8 ratio increased, and NK cell activity was depressed. After cyanocobalamin treatment, absolute numbers and percentage of lymphocyte subgroups were elevated. Increased CD4/CD8 ratio and depressed NK cell activity were restored and levels of C3, C4, and immunoglobulins were elevated. Conclusion: These findings suggest that vitamin B-12 has important immunomodulatory effects on cellular immunity, and abnormalities in the immune system in pernicious anemia are restored by vitamin B-12 replacement therapy. Copyright (C) 2008 S. Karger AG, Basel.