Necrotizing granulomatosis and angiitis of the lungs with massive splenic necrosis and focal thrombotic granulomatous glomerulonephritis.
Necrotizing granulomatosis and angiitis of the lungs with massive splenic necrosis and focal thrombotic granulomatous glomerulonephritis.
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坏死性肉芽肿病和肺血管炎伴大量脾脏坏死和局灶性血栓性肉芽肿性肾小球肾炎。
DOI：
10.1093/ajcp/23.5.413
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发表时间：
1953
影响因子：
3.5
通讯作者：
R. Fienberg
中科院分区：
文献类型：
--
作者：
R. Fienberg
在2例临床肺和肾表现的令人困惑的混合物，尸检发现一个复杂的肉芽肿病与血管炎的肺，大面积坏死的脾和局灶性血栓性肉芽肿性肾小球肾炎。此外，在1例病例中，在许多其他器官中观察到局灶性坏死性肉芽肿，在胃肠道和泌尿生殖道中发现了类似于结节性动脉周围炎的病变。在这篇文章中，术语坏死性肉芽肿病将使用，为了简洁起见，包括整个复杂。通过对文献的检索，发现了许多关于坏死性肉芽肿病的报告，这些报告通常有不同的解释和诊断，这表明多变的表现对许多研究者来说意味着许多事情。这2例病例的发表是由于希望在一定程度上澄清由不同解释引起的混乱情况以及引起对病变的兴趣，文献中对病变的描述越来越频繁。在随后的出版物中，将讨论肺坏死性肉芽肿病伴血管炎与非典型肺炎，特别是胆固醇型肺炎的可能关系。
In 2 cases with a puzzling mixture of clinical pulmonary and renal manifestations, autopsies revealed a complex of granulomatosis with angiitis of the lungs, massive necrosis of the spleen and focal thrombotic granulomatous glomerulonephritis. In addition, in 1 of the cases, focal necrotizing granulomas were seen in many other organs, and lesions similar to those of periarteritis nodosa were found in the gastrointestinal and genitourinary tracts. In this article, the term necrotizing granulomatosis will be used, for the sake of brevity, to include the entire complex. A search through the literature revealed a number of reports of necrotizing granulomatosis often with varied interpretations and diagnoses, suggesting that the protean manifestations have meant many things to many investigators. The publication of these 2 cases is prompted by the desire to clarify somewhat the confused situation caused by the varied interpretations as well as by the interest aroused in a lesion, description of which has appeared with increasing frequency in the literature. In a subsequent publication the possible relationship of pulmonary necrotizing granulomatosis with angiitis to atypical pneumonitis, particularly of the cholesterol type, will be discussed.